GATA6_CHICK
ID GATA6_CHICK Reviewed; 387 AA.
AC P43693;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Transcription factor GATA-6;
DE AltName: Full=GATA-binding factor 6;
GN Name=GATA6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn;
RX PubMed=8083222; DOI=10.1016/s0021-9258(17)31636-8;
RA Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E.,
RA Evans T.;
RT "GATA-4/5/6, a subfamily of three transcription factors transcribed in
RT developing heart and gut.";
RL J. Biol. Chem. 269:23177-23184(1994).
CC -!- FUNCTION: Transcriptional activator. {ECO:0000250|UniProtKB:Q92908}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: More abundant in stomach, and in small intestine.
CC Lower levels in lung, liver, ovary and heart.
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DR EMBL; U11889; AAA57505.1; -; mRNA.
DR PIR; I50703; I50703.
DR RefSeq; NP_990751.1; NM_205420.1.
DR AlphaFoldDB; P43693; -.
DR SMR; P43693; -.
DR STRING; 9031.ENSGALP00000030913; -.
DR PaxDb; P43693; -.
DR Ensembl; ENSGALT00000031549; ENSGALP00000030913; ENSGALG00000014976.
DR GeneID; 396390; -.
DR KEGG; gga:396390; -.
DR CTD; 2627; -.
DR VEuPathDB; HostDB:geneid_396390; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000160814; -.
DR HOGENOM; CLU_027524_0_1_1; -.
DR InParanoid; P43693; -.
DR OMA; ENSMLHC; -.
DR OrthoDB; 807790at2759; -.
DR PhylomeDB; P43693; -.
DR PRO; PR:P43693; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000014976; Expressed in liver and 10 other tissues.
DR ExpressionAtlas; P43693; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; -; 2.
DR InterPro; IPR008013; GATA_N.
DR InterPro; IPR016375; TF_GATA_4/5/6.
DR InterPro; IPR028437; TF_GATA_6.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR PANTHER; PTHR10071:SF23; PTHR10071:SF23; 1.
DR Pfam; PF00320; GATA; 2.
DR Pfam; PF05349; GATA-N; 1.
DR PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..387
FT /note="Transcription factor GATA-6"
FT /id="PRO_0000083427"
FT ZN_FING 181..205
FT /note="GATA-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT ZN_FING 235..259
FT /note="GATA-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 54..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 40249 MW; 6EEF457BB34DB2C0 CRC64;
MYQTLAISAS QGPAPYDGSP GGFMHSAPSS PVYVPTTRVG SVLPTLPYLQ GGGAAQPGHA
PAGHVWSQPA AESPSYGAAG GAHPSGRFPY SASPPVANGA SREQYGGGLA AREQYGALPR
PLNGSYPAPY ASYVGPQLGP AWPAAPFENS VLHCLQGRAA PIPVRAPSAE LLEDLSESRE
CVNCGSIQTP LWRRDGTGNY LCNACGLYTK MNGLSRPLIK PQKRVPSSRR LGLSCANCHT
TTTTLWRRNA EGEPVCNACG LYMKLHGVPR PLAMKKEGIQ TRKRKPKNIN KSKACSGNST
TAVPMTPTST SSTNSDDCSK NASPSTQPAA SGASSSVMSG PGESTSPESS NLKYSGQDGL
YTGVSLTSTA EVTASVRQDH WCALALA