GATAB_BOMMO
ID GATAB_BOMMO Reviewed; 508 AA.
AC P52167;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Transcription factor BCFI;
DE AltName: Full=BmGATA-beta;
DE Short=GATA-beta;
GN Name=GATA-B;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RX PubMed=8144656; DOI=10.1016/s0021-9258(17)34110-8;
RA Drevet J.R., Skeiky Y.A., Iatrou K.;
RT "GATA-type zinc finger motif-containing sequences and chorion gene
RT transcription factors of the silkworm Bombyx mori.";
RL J. Biol. Chem. 269:10660-10667(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 196-508, AND ALTERNATIVE
RP SPLICING.
RC STRAIN=703;
RX PubMed=7853403; DOI=10.1006/jmbi.1994.0064;
RA Drevet J.R., Swevers L., Iatrou K.;
RT "Developmental regulation of a silkworm gene encoding multiple GATA-type
RT transcription factors by alternative splicing.";
RL J. Mol. Biol. 246:43-53(1995).
CC -!- FUNCTION: Regulates the expression of chorion genes through binding to
CC gene promoter elements identical to those recognized by the GATA family
CC of transcription factors. Isoform 1 may act as a gonad-specific trans-
CC activator while isoform 2 and isoform 3 may serve as ubiquitous
CC transcriptional modulators.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P52167-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P52167-2; Sequence=VSP_001599;
CC Name=3;
CC IsoId=P52167-3; Sequence=VSP_001600;
CC -!- TISSUE SPECIFICITY: Isoform 1 is present in the ovary and the testis,
CC isoform 2 is found in the larval and pupal tissues, while isoform 3 is
CC found only in some pupal tissues.
CC -!- DEVELOPMENTAL STAGE: First appears in follicular cells at late
CC vitellogenic stages that is approximately 12 hours prior to the onset
CC of choriogenesis, its accumulation declines at the onset of
CC choriogenesis and is present at lower levels throughout choriogenesis.
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DR EMBL; L27451; AAA65734.1; -; mRNA.
DR EMBL; U16320; AAA67886.1; -; Genomic_DNA.
DR EMBL; U16320; AAA67885.1; -; Genomic_DNA.
DR EMBL; U16274; AAC13781.1; -; mRNA.
DR EMBL; U16320; AAA67887.1; -; Genomic_DNA.
DR PIR; A53741; A53741.
DR RefSeq; NP_001037446.1; NM_001043981.1.
DR AlphaFoldDB; P52167; -.
DR SMR; P52167; -.
DR GeneID; 693014; -.
DR KEGG; bmor:693014; -.
DR CTD; 693014; -.
DR eggNOG; KOG1601; Eukaryota.
DR InParanoid; P52167; -.
DR OrthoDB; 1240204at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; -; 2.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR Pfam; PF00320; GATA; 2.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..508
FT /note="Transcription factor BCFI"
FT /id="PRO_0000083459"
FT ZN_FING 269..293
FT /note="GATA-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT ZN_FING 322..346
FT /note="GATA-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 50..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 196..312
FT /note="AGARSAVAGRIFRVVNDIYAAMGIHNMFIDADLGGVITPGFGLGKVKGGRQA
FT GVELTFMRTVELAEFFTEGRECVNCGAIHTPLWHRDGTGHYLCNACGLYNKMNGMNRPL
FT KQPRRL -> TRGPPPSTERQLWPPTRTHTRGGAWSATAGRSSPQPTDSLQWPRRGPSG
FT ADFYKGFLLNGIQASHALPAPQRTRVPILLTTSRRKG (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_001600"
FT VAR_SEQ 312
FT /note="L -> LVRQRHAALAAPPHD (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_001599"
FT CONFLICT 314
FT /note="A -> G (in Ref. 2; AAC13781)"
FT /evidence="ECO:0000305"
FT CONFLICT 445
FT /note="R -> RR (in Ref. 1; AAA65734 and 2; AAC13781)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 508 AA; 56660 MW; 174C6FB6A0EB7AC3 CRC64;
MDATMQTTKH EYQFEGAAEC GYPPGRTGLS PAAQLPGAAA AHSLDMQPYS HLDDSLFKPP
TPGSAPPTAS TCAGVPSSAP RRRPRRLRPP APLHYDDYAP PPPYSHDHHH HLEQGGGGNG
AASRCTAVRL QQRRAILHQR SRPLRPAAAL DRVRRVSELR QQRDTGGRIR RERAEGWGSP
CRLSTRGSAA PSPAPAGARS AVAGRIFRVV NDIYAAMGIH NMFIDADLGG VITPGFGLGK
VKGGRQAGVE LTFMRTVELA EFFTEGRECV NCGAIHTPLW HRDGTGHYLC NACGLYNKMN
GMNRPLKQPR RLMAAKRPGT MCTNCQTTAT SLWRRNVQGE TVCNACGLYF KLHNVNRPLT
MKKDSIQTRK RKPKNSNIKA DRSAKAVQRA SPRASRWRAY WMRRRSPPRL GYYVQSAEGM
KLEEPQHHVM YIGVPELGPD TRTRRTTTTP PCRSPAETSR PTPNIIIIIS TFVVYICTCV
IELPRSDRRR RRRRRSPPKY TFTRHDYI
