ALIA_STRPN
ID ALIA_STRPN Reviewed; 660 AA.
AC P35592; O52228; O54620; Q54782;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2001, sequence version 4.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Oligopeptide-binding protein AliA;
DE AltName: Full=Exported protein 1;
DE Flags: Precursor;
GN Name=aliA; Synonyms=exp1, plpA; OrderedLocusNames=SP_0366;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R6 / R800;
RX PubMed=8051706; DOI=10.1006/jmbi.1994.1472;
RA Alloing G., de Philip P., Claverys J.-P.;
RT "Three highly homologous membrane-bound lipoproteins participate in
RT oligopeptide transport by the Ami system of the Gram-positive Streptococcus
RT pneumoniae.";
RL J. Mol. Biol. 241:44-58(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCTC 11906 / Serotype 19F, SP-496 / Serotype 19F,
RC SP-VA92 / Serotype 19F, and SP-VA96 / Serotype 19F;
RX PubMed=9466257; DOI=10.1046/j.1365-2958.1998.00658.x;
RA Coffey T.J., Enright M.C., Daniels M., Morona J.K., Morona R.,
RA Hryniewicz W., Paton J.C., Spratt B.G.;
RT "Recombinational exchanges at the capsular polysaccharide biosynthetic
RT locus lead to frequent serotype changes among natural isolates of
RT Streptococcus pneumoniae.";
RL Mol. Microbiol. 27:73-83(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-660.
RC STRAIN=R6x;
RX PubMed=7523829; DOI=10.1111/j.1365-2958.1994.tb01076.x;
RA Pearce B., Naughton A.M., Masure H.R.;
RT "Peptide permeases modulate transformation in Streptococcus pneumoniae.";
RL Mol. Microbiol. 12:881-892(1994).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 347-509.
RC STRAIN=R6x;
RX PubMed=7934910; DOI=10.1111/j.1365-2958.1993.tb01233.x;
RA Pearce B.J., Yin Y.B., Masure H.R.;
RT "Genetic identification of exported proteins in Streptococcus pneumoniae.";
RL Mol. Microbiol. 9:1037-1050(1993).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC oligopeptides; probably an oligopeptide binding protein.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 5 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK74534.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; Z35135; CAA84507.1; -; Genomic_DNA.
DR EMBL; AE005672; AAK74534.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF030359; AAC38676.1; -; Genomic_DNA.
DR EMBL; AF030360; AAC38681.1; -; Genomic_DNA.
DR EMBL; AF030361; AAC38686.1; -; Genomic_DNA.
DR EMBL; AF030364; AAC38703.1; -; Genomic_DNA.
DR EMBL; L20556; AAA26952.1; -; Genomic_DNA.
DR PIR; E95042; E95042.
DR PIR; S54395; S54395.
DR RefSeq; WP_000842584.1; NZ_AKVY01000001.1.
DR AlphaFoldDB; P35592; -.
DR SMR; P35592; -.
DR STRING; 170187.SP_0366; -.
DR PRIDE; P35592; -.
DR EnsemblBacteria; AAK74534; AAK74534; SP_0366.
DR KEGG; spn:SP_0366; -.
DR eggNOG; COG4166; Bacteria.
DR OMA; RIAYQAQ; -.
DR PhylomeDB; P35592; -.
DR BioCyc; SPNE170187:G1FZB-377-MON; -.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProt.
DR GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR030678; Peptide/Ni-bd.
DR InterPro; IPR039424; SBP_5.
DR InterPro; IPR023765; SBP_5_CS.
DR InterPro; IPR000914; SBP_5_dom.
DR PANTHER; PTHR30290; PTHR30290; 1.
DR Pfam; PF00496; SBP_bac_5; 1.
DR PIRSF; PIRSF002741; MppA; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS01040; SBP_BACTERIAL_5; 1.
PE 3: Inferred from homology;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Peptide transport;
KW Protein transport; Signal; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000305"
FT CHAIN 23..660
FT /note="Oligopeptide-binding protein AliA"
FT /id="PRO_0000031784"
FT REGION 638..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 23
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 23
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
FT VARIANT 7
FT /note="F -> L (in strain: R6 / R800)"
FT VARIANT 27
FT /note="G -> D (in strain: NCTC 11906, SP-VA92, SP-496 and
FT SP-VA96)"
FT VARIANT 30
FT /note="T -> A (in strain: R6 / R800 and R6x)"
FT VARIANT 166
FT /note="E -> D (in strain: NCTC 11906, SP-VA92, SP-496 and
FT SP-VA96)"
FT VARIANT 246
FT /note="V -> I (in strain: R6 / R800 and R6x)"
FT VARIANT 368
FT /note="L -> I (in strain: NCTC 11906, SP-VA92, SP-496 and
FT SP-VA96)"
FT VARIANT 432
FT /note="Q -> T (in strain: R6 / R800, R6x, NCTC 11906, SP-
FT VA92, SP-496 and SP-VA96)"
FT VARIANT 559
FT /note="T -> A (in strain: NCTC 11906, SP-VA92, SP-496 and
FT SP-VA96)"
FT VARIANT 612
FT /note="T -> A (in strain: SP-496)"
FT CONFLICT 18..19
FT /note="TT -> GV (in Ref. 4; AAA26952)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="L -> P (in Ref. 4; AAA26952)"
FT /evidence="ECO:0000305"
FT CONFLICT 420
FT /note="A -> R (in Ref. 1; CAA84507)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 660 AA; 73080 MW; 702556F92EC055E8 CRC64;
MKSSKLFALA GVTLLAATTL AACSGSGSST KGEKTFSYIY ETDPDNLNYL TTAKAATANI
TSNVVDGLLE NDRYGNFVPS MAEDWSVSKD GLTYTYTIRK DAKWYTSEGE EYAAVKAQDF
VTGLKYAADK KSDALYLVQE SIKGLDAYVK GEIKDFSQVG IKALDEQTVQ YTLNKPESFW
NSKTTMGVLA PVNEEFLNSK GDDFAKATDP SSLLYNGPYL LKSIVTKSSV EFAKNPNYWD
KDNVHVDKVK LSFWDGQDTS KPAENFKDGS LTAARLYPTS ASFAELEKSM KDNIVYTQQD
SITYLVGTNI DRQSYKYTSK TSDEQKASTK KALLNKDFRQ AIAFGFDRTA YASQLNGQTG
ASKILRNLFV PPTFVQADGK NFGDMVKEKL VTYGDEWKDV NLADSQDGLY NPEKAKAEFA
KAKSALQAEG VQFPIHLDMP VDQTATTKVQ RVQSMKQSLE ATLGADNVII DIQQLQKDEV
NNITYFAENA AGEDWDLSDN VGWGPDFADP STYLDIIKPS VGESTKTYLG FDSGEDNVAA
KKVGLYDYEK LVTEAGDETT DVAKRYDKYA AAQAWLTDSA LIIPTTSRTG RPILSKMVPF
TIPFALSGNK GTSEPVLYKY LELQDKAVTV DEYQKAQEKW MKEKEESNKK AQEDLAKHVK
