ID   3NO2A_NAJNI             Reviewed;          65 AA.
AC   P25680;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Weak toxin CM-10;
OS   Naja nivea (Cape cobra) (Coluber niveus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8655;
RN   [1]
RP   PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=7380387; DOI=10.1515/bchm2.1980.361.1.425;
RA   Joubert F.J., Taljaard N.;
RT   "Snake venoms. The amino acid sequences of two Melanoleuca-type toxins.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 361:425-436(1980).
CC   -!- FUNCTION: Binds with low affinity to muscular (alpha-1-beta-1-delta-
CC       epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and very low affinity to neuronal
CC       (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR).
CC       {ECO:0000250|UniProtKB:O42255}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7380387}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is 16 mg/kg by intravenous injection.
CC       {ECO:0000269|PubMed:7380387}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. Orphan group II sub-subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P25680; -.
DR   SMR; P25680; -.
DR   PRIDE; P25680; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..65
FT                   /note="Weak toxin CM-10"
FT                   /evidence="ECO:0000269|PubMed:7380387"
FT                   /id="PRO_0000093633"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        6..11
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        17..42
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        46..57
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        58..63
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
SQ   SEQUENCE   65 AA;  7545 MW;  E8FD37000C1DBB8C CRC64;
     LRCLNCPEVF CRNFHTCRNG EKICFKRFDQ RKLLGKRYTR GCAVTCPVAK PREIVECCST
     DGCNR