ID   ALKB6_XENLA             Reviewed;         240 AA.
AC   Q5PQ59;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6;
DE            EC=1.14.11.-;
DE   AltName: Full=Alkylated DNA repair protein alkB homolog 6;
GN   Name=alkbh6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable dioxygenase that requires molecular oxygen, alpha-
CC       ketoglutarate and iron. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00805};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000255|PROSITE-
CC       ProRule:PRU00805};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alkB family. {ECO:0000305}.
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DR   EMBL; BC087349; AAH87349.1; -; mRNA.
DR   RefSeq; NP_001088709.1; NM_001095240.1.
DR   RefSeq; XP_018084621.1; XM_018229132.1.
DR   AlphaFoldDB; Q5PQ59; -.
DR   SMR; Q5PQ59; -.
DR   DNASU; 495973; -.
DR   GeneID; 495973; -.
DR   KEGG; xla:495973; -.
DR   CTD; 495973; -.
DR   Xenbase; XB-GENE-5891959; alkbh6.L.
DR   OrthoDB; 1573279at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 495973; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.590; -; 1.
DR   InterPro; IPR027450; AlkB-like.
DR   InterPro; IPR037151; AlkB-like_sf.
DR   InterPro; IPR032862; ALKBH6.
DR   InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR   PANTHER; PTHR46030; PTHR46030; 1.
DR   Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..240
FT                   /note="Alpha-ketoglutarate-dependent dioxygenase alkB
FT                   homolog 6"
FT                   /id="PRO_0000323719"
FT   DOMAIN          95..227
FT                   /note="Fe2OG dioxygenase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT   BINDING         102..104
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250"
FT   BINDING         113
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT   BINDING         115
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT   BINDING         185
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT   BINDING         218..224
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   240 AA;  27077 MW;  045F2D1CF573951E CRC64;
     MQACHNFPDL DSFLVEKIPL AAYYVPEYIS KSEEEYLLRQ VYNAPKPKWT QLSGRKLQNW
     GGLPHSRGMV QEKLPSWLQK YTDQISSLGV FGDHSANHVL VNEYNAGEGI MPHEDGPMYY
     PTVTTISLGS HTLLDFYVPI NKECQETQNQ DKVASTEEQR HMLSLLLEPR SLLVVREELY
     TSYLHGICPR TSDTLSPMVA NLGNSTAHAG DTLQRGTRVS LTIRFVPKVL KTSLLLGKGR