ID   3NO2B_NAJME             Reviewed;          65 AA.
AC   P01400;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Weak toxin S4C11;
OS   Naja melanoleuca (Forest cobra) (Black-lipped cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8643;
RN   [1]
RP   PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=1164509; DOI=10.1016/0005-2795(75)90186-5;
RA   Carlsson F.H.H.;
RT   "Snake venom toxins. The primary structure of protein S4C11. A neurotoxin
RT   homologue from the venom of forest cobra (Naja melanoleuca).";
RL   Biochim. Biophys. Acta 400:310-321(1975).
CC   -!- FUNCTION: Binds with low affinity to muscular (alpha-1-beta-1-delta-
CC       epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and very low affinity to neuronal
CC       (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR).
CC       {ECO:0000250|UniProtKB:O42255}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1164509}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is >20 mg/kg by intravenous injection.
CC       {ECO:0000269|PubMed:1164509}.
CC   -!- MISCELLANEOUS: The geographical location for this forest cobra
CC       population was Rhodesia.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. Orphan group II sub-subfamily. {ECO:0000305}.
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DR   PIR; A01671; V6NJ4W.
DR   AlphaFoldDB; P01400; -.
DR   SMR; P01400; -.
DR   PRIDE; P01400; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..65
FT                   /note="Weak toxin S4C11"
FT                   /evidence="ECO:0000269|PubMed:1164509"
FT                   /id="PRO_0000093636"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        6..11
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        17..42
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        46..57
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        58..63
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
SQ   SEQUENCE   65 AA;  7430 MW;  07B4E9BE6B72B2E7 CRC64;
     LTCLICPEKY CNKVHTCRNG ENICFKRFYE GNLLGKRYPR GCAATCPEAK PREIVECCST
     DKCNH