ID   ALKE_BABBO              Reviewed;         285 AA.
AC   P40690;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Aldo-keto reductase;
DE   Flags: Fragment;
OS   Babesia bovis.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Babesiidae; Babesia.
OX   NCBI_TaxID=5865;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1482401;
RA   Dalrymple B.P., Peters J.M., Vuocolo T.;
RT   "Characterisation of genes encoding two novel members of the aldo-keto
RT   reductase superfamily.";
RL   Biochem. Int. 28:651-657(1992).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
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DR   EMBL; M93122; AAA27794.1; -; mRNA.
DR   AlphaFoldDB; P40690; -.
DR   SMR; P40690; -.
DR   STRING; 5865.XP_001609181.1; -.
DR   VEuPathDB; PiroplasmaDB:BBOV_IV000130; -.
DR   eggNOG; KOG1575; Eukaryota.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase.
FT   CHAIN           <1..>285
FT                   /note="Aldo-keto reductase"
FT                   /id="PRO_0000070373"
FT   BINDING         165..175
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         285
SQ   SEQUENCE   285 AA;  32470 MW;  F202CB55F3735D5F CRC64;
     SKVVIATKVA SRSSHLSWLR SGDCKLSKDN ILKAVDGSLS RLNTDYIDLL QLHWPDRYVP
     MNANGDFHEV FHDTENMIDE NSVPLEDQLD ALQTLLTQGK IRHWGLSNET PWGTLRFYKL
     AKQAGVAAPA SVQLHYNLLC RNEVEKGFVE LCRPQNTGIA ILAYAPLAGG ILTGKYLEYM
     DPTTSGRLLR FPSYMSRYRG SLAARAVKDY YNIAMSYKYP NLCALALRWV LTRPFICSTV
     IGANDFYQLR ENIHCSMPSL GITDLLEREI NQLHWKWRDP IRICQ