ALKL1_DANRE
ID ALKL1_DANRE Reviewed; 152 AA.
AC F8W2C9;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=ALK and LTK ligand 1 {ECO:0000303|PubMed:29317532};
DE AltName: Full=Augmentor beta {ECO:0000303|PubMed:29078341};
DE Short=AUG-beta {ECO:0000303|PubMed:29078341};
DE Flags: Precursor;
GN Name=alkal1 {ECO:0000303|PubMed:29317532,
GN ECO:0000312|ZFIN:ZDB-GENE-110411-243};
GN ORFNames=si:dkey-30h22.10 {ECO:0000312|ZFIN:ZDB-GENE-110411-243};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP FUNCTION.
RX PubMed=29078341; DOI=10.1073/pnas.1710254114;
RA Mo E.S., Cheng Q., Reshetnyak A.V., Schlessinger J., Nicoli S.;
RT "Alk and Ltk ligands are essential for iridophore development in zebrafish
RT mediated by the receptor tyrosine kinase Ltk.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:12027-12032(2017).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=29317532; DOI=10.1073/pnas.1719137115;
RA Fadeev A., Mendoza-Garcia P., Irion U., Guan J., Pfeifer K., Wiessner S.,
RA Serluca F., Singh A.P., Nuesslein-Volhard C., Palmer R.H.;
RT "ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the
RT neural crest and derived cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 115:E630-E638(2018).
CC -!- FUNCTION: Cytokine that acts as a physiological ligand for receptor
CC tyrosine kinases LTK and ALK (PubMed:29078341, PubMed:29317532).
CC Required for iridophore development in the adult eye by acting as a
CC receptor for LTK (PubMed:29078341). {ECO:0000269|PubMed:29078341,
CC ECO:0000269|PubMed:29317532}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255}. Cell membrane
CC {ECO:0000250|UniProtKB:Q6UXT8}.
CC -!- TISSUE SPECIFICITY: Expressed at low level in the notochord and
CC iridophore stripes, the eye and the swim bladder.
CC {ECO:0000269|PubMed:29317532}.
CC -!- DISRUPTION PHENOTYPE: Fishes show reduced iridophores in eyes and
CC operculum, with no detectable phenotype in the trunk (PubMed:29317532).
CC Fishes lacking both alkal1 and alkal2b show a complete loss of eye
CC iridophores (PubMed:29317532). Fishes lacking alkal1, alkal2a and
CC alkal2b are embryonic lethal and display total loss of iridophores
CC (PubMed:29317532). {ECO:0000269|PubMed:29317532}.
CC -!- SIMILARITY: Belongs to the ALKAL family. {ECO:0000305}.
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DR EMBL; AL844185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003199108.1; XM_003199060.4.
DR SMR; F8W2C9; -.
DR STRING; 7955.ENSDARP00000124157; -.
DR PaxDb; F8W2C9; -.
DR Ensembl; ENSDART00000148958; ENSDARP00000124774; ENSDARG00000074387.
DR Ensembl; ENSDART00000149860; ENSDARP00000124157; ENSDARG00000074387.
DR GeneID; 100535009; -.
DR KEGG; dre:100535009; -.
DR CTD; 389658; -.
DR ZFIN; ZDB-GENE-110411-243; alkal1.
DR eggNOG; ENOG502RZG1; Eukaryota.
DR GeneTree; ENSGT00940000159969; -.
DR HOGENOM; CLU_120534_0_0_1; -.
DR InParanoid; F8W2C9; -.
DR OrthoDB; 1432187at2759; -.
DR PhylomeDB; F8W2C9; -.
DR TreeFam; TF333390; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000074387; Expressed in retina and 7 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IDA:UniProtKB.
DR GO; GO:0030298; F:receptor signaling protein tyrosine kinase activator activity; IDA:UniProtKB.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0050935; P:iridophore differentiation; IMP:ZFIN.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0070378; P:positive regulation of ERK5 cascade; IBA:GO_Central.
DR InterPro; IPR029364; FAM150A/B.
DR PANTHER; PTHR28676; PTHR28676; 1.
DR Pfam; PF15129; FAM150; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytokine; Disulfide bond; Membrane; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..152
FT /note="ALK and LTK ligand 1"
FT /id="PRO_5015091373"
FT DISULFID 113..149
FT /evidence="ECO:0000250|UniProtKB:Q6UXT8"
FT DISULFID 127..136
FT /evidence="ECO:0000250|UniProtKB:Q6UXT8"
SQ SEQUENCE 152 AA; 17607 MW; E5CB2A91B492BE81 CRC64;
MRAEKRWHIL LSMILLLITS SQCMDSKEVK ESERKTLLNL ILQVIGEKPA SRRVTSGLYS
VSQDAKFSSR ENTAHLPKPD NSRPIEIVPR DTSMKDKFIE HFTAGPVKFP SECRTHFHRI
YHNTRDCSRP TYYKRCARLL TRLAMSPLCT QS
