ALKL2_MOUSE
ID ALKL2_MOUSE Reviewed; 151 AA.
AC Q80UG6; G3X9F3;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=ALK and LTK ligand 2;
DE Flags: Precursor;
GN Name=Alkal2 {ECO:0000312|MGI:MGI:3697448};
GN Synonyms=Fam150b {ECO:0000312|MGI:MGI:3697448};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cytokine that acts as a physiological ligand for receptor
CC tyrosine kinases LTK and ALK, leading to their activation. Cytokine-
CC binding is sufficient to activate LTK. In contrast, ALKAL2-driven
CC activation of ALK is coupled with heparin-binding to ALK. Stimulation
CC of ALK signaling is involved in neural development and regulation of
CC energy expenditure. {ECO:0000250|UniProtKB:Q6UX46}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q6UX46}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell
CC membrane {ECO:0000250|UniProtKB:Q6UX46}. Note=Following interaction
CC with receptor tyrosine kinase ALK, associates with the cell membrane,
CC membrane-binding is required to activate ALK.
CC {ECO:0000250|UniProtKB:Q6UX46}.
CC -!- SIMILARITY: Belongs to the ALKAL family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH46522.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC160932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466526; EDL36927.1; -; Genomic_DNA.
DR EMBL; BC046522; AAH46522.1; ALT_INIT; mRNA.
DR CCDS; CCDS49044.1; -.
DR RefSeq; NP_001153215.1; NM_001159743.1.
DR AlphaFoldDB; Q80UG6; -.
DR SMR; Q80UG6; -.
DR STRING; 10090.ENSMUSP00000070037; -.
DR PaxDb; Q80UG6; -.
DR PRIDE; Q80UG6; -.
DR Antibodypedia; 62864; 2 antibodies from 1 providers.
DR Ensembl; ENSMUST00000067087; ENSMUSP00000070037; ENSMUSG00000054204.
DR GeneID; 100294583; -.
DR KEGG; mmu:100294583; -.
DR UCSC; uc007ngv.1; mouse.
DR CTD; 285016; -.
DR MGI; MGI:3697448; Alkal2.
DR VEuPathDB; HostDB:ENSMUSG00000054204; -.
DR eggNOG; ENOG502S2JY; Eukaryota.
DR GeneTree; ENSGT00940000162505; -.
DR HOGENOM; CLU_120534_0_0_1; -.
DR InParanoid; Q80UG6; -.
DR OMA; SPMCMER; -.
DR OrthoDB; 1432187at2759; -.
DR PhylomeDB; Q80UG6; -.
DR TreeFam; TF333390; -.
DR BioGRID-ORCS; 100294583; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q80UG6; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q80UG6; protein.
DR Bgee; ENSMUSG00000054204; Expressed in uterus and 35 other tissues.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR GO; GO:0030298; F:receptor signaling protein tyrosine kinase activator activity; ISS:UniProtKB.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:0070378; P:positive regulation of ERK5 cascade; ISO:MGI.
DR GO; GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.
DR InterPro; IPR029364; FAM150A/B.
DR PANTHER; PTHR28676; PTHR28676; 1.
DR Pfam; PF15129; FAM150; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytokine; Disulfide bond; Membrane; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..151
FT /note="ALK and LTK ligand 2"
FT /id="PRO_0000353120"
FT DISULFID 112..148
FT /evidence="ECO:0000250|UniProtKB:Q6UX46"
FT DISULFID 126..135
FT /evidence="ECO:0000250|UniProtKB:Q6UX46"
FT CONFLICT 17
FT /note="S -> T (in Ref. 3; AAH46522)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 151 AA; 17496 MW; B4ADE435B373CCB7 CRC64;
MRVSGRPMLL ALLLLLSTVG DRGRAQSRGP ADRQTLLRLL VELVQELKKF HIGDSKRLQL
LGESDFALGR REATDYGADQ EEQRVEIVPR DLRMKDKFLK HLTGPLYFSP KCSKHFHRLY
HNTRDCTIPA YYKRCARLLT RLAVSPMCME R
