ID   ALKL2_RAT               Reviewed;         151 AA.
AC   B2RZ42;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=ALK and LTK ligand 2;
DE   Flags: Precursor;
GN   Name=Alkal2 {ECO:0000312|RGD:1587117};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cytokine that acts as a physiological ligand for receptor
CC       tyrosine kinases LTK and ALK, leading to their activation. Cytokine-
CC       binding is sufficient to activate LTK. In contrast, ALKAL2-driven
CC       activation of ALK is coupled with heparin-binding to ALK. Stimulation
CC       of ALK signaling is involved in neural development and regulation of
CC       energy expenditure. {ECO:0000250|UniProtKB:Q6UX46}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q6UX46}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell
CC       membrane {ECO:0000250|UniProtKB:Q6UX46}. Note=Following interaction
CC       with receptor tyrosine kinase ALK, associates with the cell membrane,
CC       membrane-binding is required to activate ALK.
CC       {ECO:0000250|UniProtKB:Q6UX46}.
CC   -!- SIMILARITY: Belongs to the ALKAL family. {ECO:0000305}.
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DR   EMBL; CH473947; EDM03239.1; -; Genomic_DNA.
DR   EMBL; BC167018; AAI67018.1; -; mRNA.
DR   RefSeq; NP_001102842.1; NM_001109372.1.
DR   AlphaFoldDB; B2RZ42; -.
DR   SMR; B2RZ42; -.
DR   STRING; 10116.ENSRNOP00000006921; -.
DR   PaxDb; B2RZ42; -.
DR   Ensembl; ENSRNOT00000006921; ENSRNOP00000006921; ENSRNOG00000005154.
DR   GeneID; 679566; -.
DR   KEGG; rno:679566; -.
DR   UCSC; RGD:1587117; rat.
DR   CTD; 285016; -.
DR   RGD; 1587117; Alkal2.
DR   eggNOG; ENOG502S2JY; Eukaryota.
DR   GeneTree; ENSGT00940000162505; -.
DR   HOGENOM; CLU_120534_0_0_1; -.
DR   InParanoid; B2RZ42; -.
DR   OMA; SPMCMER; -.
DR   OrthoDB; 1432187at2759; -.
DR   PhylomeDB; B2RZ42; -.
DR   TreeFam; TF333390; -.
DR   PRO; PR:B2RZ42; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Proteomes; UP000234681; Chromosome 6.
DR   Bgee; ENSRNOG00000005154; Expressed in heart and 8 other tissues.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR   GO; GO:0030298; F:receptor signaling protein tyrosine kinase activator activity; ISS:UniProtKB.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; ISO:RGD.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
DR   GO; GO:0070378; P:positive regulation of ERK5 cascade; ISO:RGD.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.
DR   InterPro; IPR029364; FAM150A/B.
DR   PANTHER; PTHR28676; PTHR28676; 1.
DR   Pfam; PF15129; FAM150; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytokine; Disulfide bond; Membrane; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..151
FT                   /note="ALK and LTK ligand 2"
FT                   /id="PRO_0000353121"
FT   DISULFID        112..148
FT                   /evidence="ECO:0000250|UniProtKB:Q6UX46"
FT   DISULFID        126..135
FT                   /evidence="ECO:0000250|UniProtKB:Q6UX46"
SQ   SEQUENCE   151 AA;  17428 MW;  6CB9ECE6D2B62FBB CRC64;
     MRVSGRPMLL ALLLLLSTVG DPGHAQPRGP ADRQTLLRLL VELVQELKKF HIGDSKRLQL
     LGESDFALGR REATDYGADQ EEQRVEIVPR DLRMKDKFLK HLTGPLYFSP KCSKHFHRLY
     HNTRDCTIPA YYKRCARLLT RLAVSPMCME R