ALKR1_ARATH
ID ALKR1_ARATH Reviewed; 344 AA.
AC Q9C5B9; Q67YQ4; Q9SAC2;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Probable aldo-keto reductase 1;
DE EC=1.1.1.-;
GN OrderedLocusNames=At1g10810; ORFNames=T16B5.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD31332.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007354; AAD31332.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28648.1; -; Genomic_DNA.
DR EMBL; AF361098; AAK27238.1; -; mRNA.
DR EMBL; AK176341; BAD44104.1; -; mRNA.
DR EMBL; AK176414; BAD44177.1; -; mRNA.
DR PIR; G86241; G86241.
DR RefSeq; NP_172551.1; NM_100957.3.
DR AlphaFoldDB; Q9C5B9; -.
DR SMR; Q9C5B9; -.
DR STRING; 3702.AT1G10810.1; -.
DR PaxDb; Q9C5B9; -.
DR ProteomicsDB; 245017; -.
DR EnsemblPlants; AT1G10810.1; AT1G10810.1; AT1G10810.
DR GeneID; 837624; -.
DR Gramene; AT1G10810.1; AT1G10810.1; AT1G10810.
DR KEGG; ath:AT1G10810; -.
DR Araport; AT1G10810; -.
DR TAIR; locus:2196446; AT1G10810.
DR eggNOG; KOG1575; Eukaryota.
DR HOGENOM; CLU_023205_2_1_1; -.
DR InParanoid; Q9C5B9; -.
DR OMA; EHNKQIF; -.
DR OrthoDB; 1136766at2759; -.
DR PhylomeDB; Q9C5B9; -.
DR BioCyc; ARA:AT1G10810-MON; -.
DR PRO; PR:Q9C5B9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C5B9; baseline and differential.
DR Genevisible; Q9C5B9; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IBA:GO_Central.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR SUPFAM; SSF51430; SSF51430; 1.
PE 2: Evidence at transcript level;
KW NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..344
FT /note="Probable aldo-keto reductase 1"
FT /id="PRO_0000415740"
FT ACT_SITE 63
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 130
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 209..219
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT CONFLICT 108
FT /note="V -> A (in Ref. 4; BAD44104/BAD44177)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 344 AA; 37596 MW; B2DD55D39C93F7CF CRC64;
MAAASGVRRI KLGSQGLEVS AQGLGCMGLS IFDGTTKVET DLIALIHHAI NSGITLLDTS
DIYGPETNEL LLGQALKDGM REKVELATKF GLLLKDQKLG YRGDPAYVRA ACEASLRRLG
VSCIDLYYQH RIDTTVPIEV TIGELKKLVE EGKIKYIGLS EACASTIRRA HAVHPLTAVQ
LEWSLWSRDV EEDIIPTCRE LGIGIVAYSP LGLGFFAAGP KFIESMDNGD YRKGLPRFQQ
ENLDHNKILY EKVNAMAEKK SCTPAQLALA WVHHQGNDVC PIPGTSKIKN LNQNIGALSV
KLSIEEMAEL DAMGHPDSVK GERSATYIVT YKNSETPPLS SWTS
