ALKR3_ARATH
ID ALKR3_ARATH Reviewed; 345 AA.
AC O22707;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Probable aldo-keto reductase 3;
DE EC=1.1.1.-;
GN OrderedLocusNames=At1g60690; ORFNames=F8A5.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR EMBL; AC002292; AAB71981.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33720.1; -; Genomic_DNA.
DR PIR; C96632; C96632.
DR RefSeq; NP_176268.1; NM_104752.2.
DR AlphaFoldDB; O22707; -.
DR SMR; O22707; -.
DR STRING; 3702.AT1G60690.1; -.
DR PaxDb; O22707; -.
DR PRIDE; O22707; -.
DR ProteomicsDB; 245048; -.
DR EnsemblPlants; AT1G60690.1; AT1G60690.1; AT1G60690.
DR GeneID; 842363; -.
DR Gramene; AT1G60690.1; AT1G60690.1; AT1G60690.
DR KEGG; ath:AT1G60690; -.
DR Araport; AT1G60690; -.
DR TAIR; locus:2036611; AT1G60690.
DR eggNOG; KOG1575; Eukaryota.
DR HOGENOM; CLU_023205_2_1_1; -.
DR InParanoid; O22707; -.
DR OMA; DAAKPHG; -.
DR OrthoDB; 1136766at2759; -.
DR PhylomeDB; O22707; -.
DR BioCyc; ARA:AT1G60690-MON; -.
DR PRO; PR:O22707; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O22707; baseline and differential.
DR Genevisible; O22707; AT.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IBA:GO_Central.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR SUPFAM; SSF51430; SSF51430; 1.
PE 3: Inferred from homology;
KW NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..345
FT /note="Probable aldo-keto reductase 3"
FT /id="PRO_0000415742"
FT ACT_SITE 63
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 130
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 209..219
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
SQ SEQUENCE 345 AA; 38161 MW; 2A76F87D711B29EE CRC64;
MAESCRVRRI KLGSQGLEVS AQGLGCMGLT GHYGASKPET EAIALIHHAI HSGVTFLDTS
DMYGPETNEI LLGKALKDGV REKVELATKF GISYAEGNRE IKGDPAYVRA ACEASLKRLD
VTCIDLYYQH RIDTRVPIEI TMGELKKLIE EGKIKYIGLS EASASTIRRA HTVHPITAVQ
LEWSLWTRDV EEEIVPTCRE LGIGIVSYSP LGRGFFASGP KLVENLDNND FRKALPRFQQ
ENLDHNKILY EKVSAMSEKK GCTPAQLALA WVHHQGDDVC PIPGTTKIEN LNQNIRALSV
KLTPEEMSEL ETIAQPESVK GERYMATVPT FKNSDTPPLS SWNAV
