ALKR4_ARATH
ID ALKR4_ARATH Reviewed; 345 AA.
AC Q93ZN2; O22709; Q42080; Q9SEX1;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Probable aldo-keto reductase 4;
DE EC=1.1.1.-;
GN OrderedLocusNames=At1g60710; ORFNames=F8A5.23;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15208421; DOI=10.1104/pp.104.040030;
RA Boivin K., Acarkan A., Mbulu R.S., Clarenz O., Schmidt R.;
RT "The Arabidopsis genome sequence as a tool for genome analysis in the
RT Brassicaceae: a comparison of the Arabidopsis thaliana and Capsella rubella
RT genomes.";
RL Plant Physiol. 135:735-744(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Spoormaker P., Palme K.;
RT "Guard cell protein.";
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 170-295.
RC STRAIN=cv. Columbia; TISSUE=Seedling;
RA Hofte H.;
RT "The Arabidopsis thaliana transcribed genome: the GDR cDNA program.";
RL Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP INDUCTION BY IRON AND SULFUR.
RX PubMed=12609038; DOI=10.1046/j.1365-313x.2003.01657.x;
RA Nikiforova V., Freitag J., Kempa S., Adamik M., Hesse H., Hoefgen R.;
RT "Transcriptome analysis of sulfur depletion in Arabidopsis thaliana:
RT interlacing of biosynthetic pathways provides response specificity.";
RL Plant J. 33:633-650(2003).
CC -!- INDUCTION: Up-regulated by iron and sulfur starvation.
CC {ECO:0000269|PubMed:12609038}.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
CC -!- CAUTION: Reported as ATB2 in TAIR. The origin of the name is unclear
CC and this protein should not be mixed with bZIP family protein ATB2.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB71960.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAB71960.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ608277; CAE55217.1; -; mRNA.
DR EMBL; AF057715; AAF17106.1; -; mRNA.
DR EMBL; AC002292; AAB71960.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33722.1; -; Genomic_DNA.
DR EMBL; AY056440; AAL08296.1; -; mRNA.
DR EMBL; AY099655; AAM20506.1; -; mRNA.
DR EMBL; BT000251; AAN15570.1; -; mRNA.
DR EMBL; Z26233; CAA81199.1; -; mRNA.
DR PIR; E96632; E96632.
DR RefSeq; NP_564761.1; NM_104754.4.
DR AlphaFoldDB; Q93ZN2; -.
DR SMR; Q93ZN2; -.
DR IntAct; Q93ZN2; 1.
DR STRING; 3702.AT1G60710.1; -.
DR MetOSite; Q93ZN2; -.
DR PaxDb; Q93ZN2; -.
DR PRIDE; Q93ZN2; -.
DR ProteomicsDB; 245074; -.
DR EnsemblPlants; AT1G60710.1; AT1G60710.1; AT1G60710.
DR GeneID; 842365; -.
DR Gramene; AT1G60710.1; AT1G60710.1; AT1G60710.
DR KEGG; ath:AT1G60710; -.
DR Araport; AT1G60710; -.
DR TAIR; locus:2036504; AT1G60710.
DR eggNOG; KOG1575; Eukaryota.
DR HOGENOM; CLU_023205_2_1_1; -.
DR InParanoid; Q93ZN2; -.
DR OMA; WGMSEAG; -.
DR OrthoDB; 1136766at2759; -.
DR PhylomeDB; Q93ZN2; -.
DR BioCyc; ARA:AT1G60710-MON; -.
DR PRO; PR:Q93ZN2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q93ZN2; baseline and differential.
DR Genevisible; Q93ZN2; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IBA:GO_Central.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; SSF51430; 1.
PE 2: Evidence at transcript level;
KW NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..345
FT /note="Probable aldo-keto reductase 4"
FT /id="PRO_0000415743"
FT ACT_SITE 63
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 130
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 209..219
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT CONFLICT 115..116
FT /note="SL -> KF (in Ref. 2; AAF17106)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="Q -> A (in Ref. 6; CAA81199)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="R -> E (in Ref. 6; CAA81199)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 37925 MW; B094ED7AFF365271 CRC64;
MAEACGVRRM KLGSQGLEVS AQGLGCMGLS AFYGAPKPEN EAIALIHHAI HSGVTLLDTS
DIYGPETNEV LLGKALKDGV REKVELATKF GISYAEGKRE VRGDPEYVRA ACEASLKRLD
IACIDLYYQH RVDTRVPIEI TMGELKKLVE EGKIKYIGLS EASASTIRRA HAVHPITAVQ
IEWSLWTRDV EEEIIPTCRE LGIGIVAYSP LGRGFFASGP KLVENLEKDD FRKALPRFQE
ENLDHNKIVY EKVCAISEKK GCTPGQLALA WVHHQGDDVC PIPGTTKIEN LKQNIGALSV
KLTPEEMTEL EAIAQPGFVK GDRYSNMIPT FKNAETPPLS AWKAA
