ID   ALKR6_ARATH             Reviewed;         330 AA.
AC   F4HPY8; O22712;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Probable aldo-keto reductase 6;
DE            EC=1.1.1.-;
GN   OrderedLocusNames=At1g60750; ORFNames=F8A5.26;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB71969.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC002292; AAB71969.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE33728.1; -; Genomic_DNA.
DR   PIR; H96632; H96632.
DR   RefSeq; NP_176274.1; NM_104758.1.
DR   AlphaFoldDB; F4HPY8; -.
DR   SMR; F4HPY8; -.
DR   STRING; 3702.AT1G60750.1; -.
DR   PaxDb; F4HPY8; -.
DR   PRIDE; F4HPY8; -.
DR   ProteomicsDB; 245018; -.
DR   EnsemblPlants; AT1G60750.1; AT1G60750.1; AT1G60750.
DR   GeneID; 3767587; -.
DR   Gramene; AT1G60750.1; AT1G60750.1; AT1G60750.
DR   KEGG; ath:AT1G60750; -.
DR   Araport; AT1G60750; -.
DR   TAIR; locus:2036551; AT1G60750.
DR   eggNOG; KOG1575; Eukaryota.
DR   HOGENOM; CLU_023205_2_1_1; -.
DR   InParanoid; F4HPY8; -.
DR   OMA; DDWRKTN; -.
DR   OrthoDB; 1136766at2759; -.
DR   PRO; PR:F4HPY8; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; F4HPY8; baseline and differential.
DR   Genevisible; F4HPY8; AT.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; HDA:TAIR.
DR   GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IBA:GO_Central.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..330
FT                   /note="Probable aldo-keto reductase 6"
FT                   /id="PRO_0000415745"
FT   ACT_SITE        64
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         132
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         211..221
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   330 AA;  36352 MW;  9FA5BEC28B7FD7B6 CRC64;
     MAEEACQVRR MKLGSQGLEV SAQGLGCMGL SDFYGAPTPE TNAVALLRHA INAGVTFLDT
     SDIYGPETNE LLLGKALKDG LRDKVELATK FGITASEDGK FGFRGDPEYV RIACEASLKR
     LGVTCIDLYY QHRIDTTLPI EITIGELKKL VEEGKIKYIG LSEASASTIR RAHAVHPITA
     VQIEWSLWSR DVEEDIIPTC RELGIGIVAY SPLGRGFLGL PRFQQENLEN NKILYEKVQA
     MATKKSCTPA QLALAWVHHQ GDDVCPIPGT SKIQNLNQNI GALSVKLTPE EMVELEAIAQ
     PDFVKGERYD NNMVTYKDSE TPPLSSWKAR