ID   ALKR_ACIAD              Reviewed;         306 AA.
AC   O31249;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=HTH-type transcriptional regulator AlkR;
GN   Name=alkR; OrderedLocusNames=ACIAD1410;
OS   Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter.
OX   NCBI_TaxID=62977;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9546151; DOI=10.1128/aem.64.4.1175-1179.1998;
RA   Ratajczak A., Geissdorfer W., Hillen W.;
RT   "Alkane hydroxylase from Acinetobacter sp. strain ADP1 is encoded by alkM
RT   and belongs to a new family of bacterial integral-membrane hydrocarbon
RT   hydroxylases.";
RL   Appl. Environ. Microbiol. 64:1175-1179(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33305 / BD413 / ADP1;
RX   PubMed=15514110; DOI=10.1093/nar/gkh910;
RA   Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA   Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA   Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT   "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT   a versatile and naturally transformation competent bacterium.";
RL   Nucleic Acids Res. 32:5766-5779(2004).
RN   [3]
RP   FUNCTION.
RX   PubMed=9811637; DOI=10.1128/jb.180.22.5822-5827.1998;
RA   Ratajczak A., Geissdorfer W., Hillen W.;
RT   "Expression of alkane hydroxylase from Acinetobacter sp. Strain ADP1 is
RT   induced by a broad range of n-alkanes and requires the transcriptional
RT   activator AlkR.";
RL   J. Bacteriol. 180:5822-5827(1998).
CC   -!- FUNCTION: This protein activates the expression of the alkane 1-
CC       monooxygenase AlkM. {ECO:0000269|PubMed:9811637}.
CC   -!- PATHWAY: Hydrocarbon metabolism; alkane degradation.
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DR   EMBL; AJ002316; CAA05332.1; -; Genomic_DNA.
DR   EMBL; CR543861; CAG68275.1; -; Genomic_DNA.
DR   RefSeq; WP_004925571.1; NC_005966.1.
DR   AlphaFoldDB; O31249; -.
DR   SMR; O31249; -.
DR   STRING; 62977.ACIAD1410; -.
DR   PRIDE; O31249; -.
DR   EnsemblBacteria; CAG68275; CAG68275; ACIAD1410.
DR   GeneID; 45233824; -.
DR   KEGG; aci:ACIAD1410; -.
DR   eggNOG; COG2207; Bacteria.
DR   HOGENOM; CLU_000445_81_0_6; -.
DR   OMA; AFMIRAC; -.
DR   OrthoDB; 1785082at2; -.
DR   BioCyc; ASP62977:ACIAD_RS06510-MON; -.
DR   UniPathway; UPA00191; -.
DR   Proteomes; UP000000430; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0043448; P:alkane catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR032783; AraC_lig.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12852; Cupin_6; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..306
FT                   /note="HTH-type transcriptional regulator AlkR"
FT                   /id="PRO_0000392225"
FT   DOMAIN          207..305
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        224..245
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        272..295
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   306 AA;  34580 MW;  2994AC21CA8A8973 CRC64;
     MDALSKIFDD IHLNKSEYLY VKTQGEWAFH MLAQDALIAH IILMGSAHFT LQDGTTQTAY
     SGDIVLIPSG QAHFVSNDAQ NKLIDCSNIQ SFFDGHRNDA IELGTTSSDH GLIFTVRSHI
     DMHMGSPLLN ALPSLIHIHH AMSSTGPEWL RVGLYFVALE TQRIQPGRDK IFDHLMSILF
     IECVRDHIAQ LDDPKSWLTA LMHPELSNAL AAIHAYPEKP WTVESLADQC CMSRSKFATL
     FQSIVHETPL AYLQQHRLRL AVQLLKTSQL NIQQIANKVG YSSETAFSQA FKRQFEQSPK
     HYRQQS