ID   ALKS_ALCBS              Reviewed;         872 AA.
AC   Q0VKZ4; Q93UQ2;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=HTH-type transcriptional regulator AlkS;
GN   Name=alkS; OrderedLocusNames=ABO_2706;
OS   Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 /
OS   SK2).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Alcanivoracaceae; Alcanivorax.
OX   NCBI_TaxID=393595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AP1;
RX   PubMed=11872724; DOI=10.1128/jb.184.6.1722-1732.2002;
RA   van Beilen J.B., Neuenschwander M., Smits T.H., Roth C., Balada S.B.,
RA   Witholt B.;
RT   "Rubredoxins involved in alkane oxidation.";
RL   J. Bacteriol. 184:1722-1732(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AP1;
RX   PubMed=11872725; DOI=10.1128/jb.184.6.1733-1742.2002;
RA   Smits T.H., Balada S.B., Witholt B., van Beilen J.B.;
RT   "Functional analysis of alkane hydroxylases from gram-negative and gram-
RT   positive bacteria.";
RL   J. Bacteriol. 184:1733-1742(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2;
RX   PubMed=16878126; DOI=10.1038/nbt1232;
RA   Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M.,
RA   Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C.,
RA   Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B.,
RA   McHardy A.C., Meyer F., Nechitaylo T., Puehler A., Regenhardt D., Rupp O.,
RA   Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J.,
RA   Weidner S., Kaiser O., Golyshin P.N.;
RT   "Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium
RT   Alcanivorax borkumensis.";
RL   Nat. Biotechnol. 24:997-1004(2006).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=14871210; DOI=10.1111/j.1462-2920.2004.00567.x;
RA   van Beilen J.B., Marin M.M., Smits T.H., Rothlisberger M., Franchini A.G.,
RA   Witholt B., Rojo F.;
RT   "Characterization of two alkane hydroxylase genes from the marine
RT   hydrocarbonoclastic bacterium Alcanivorax borkumensis.";
RL   Environ. Microbiol. 6:264-273(2004).
CC   -!- FUNCTION: This protein activates the expression of AlkB1 in the
CC       presence of alkanes. {ECO:0000269|PubMed:14871210}.
CC   -!- PATHWAY: Hydrocarbon metabolism; alkane degradation.
CC   -!- INDUCTION: Induced upon entry into stationary phase.
CC       {ECO:0000269|PubMed:14871210}.
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DR   EMBL; AJ295164; CAC38026.1; -; Genomic_DNA.
DR   EMBL; AM286690; CAL18154.1; -; Genomic_DNA.
DR   RefSeq; WP_011589977.1; NC_008260.1.
DR   AlphaFoldDB; Q0VKZ4; -.
DR   SMR; Q0VKZ4; -.
DR   STRING; 393595.ABO_2706; -.
DR   PRIDE; Q0VKZ4; -.
DR   EnsemblBacteria; CAL18154; CAL18154; ABO_2706.
DR   KEGG; abo:ABO_2706; -.
DR   eggNOG; COG2909; Bacteria.
DR   HOGENOM; CLU_006325_2_0_6; -.
DR   OMA; ICAGPGW; -.
DR   OrthoDB; 1377603at2; -.
DR   UniPathway; UPA00191; -.
DR   Proteomes; UP000008871; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0043448; P:alkane catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..872
FT                   /note="HTH-type transcriptional regulator AlkS"
FT                   /id="PRO_0000392223"
FT   DOMAIN          805..870
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        829..848
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   CONFLICT        256
FT                   /note="E -> D (in Ref. 1; CAC38026)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        730
FT                   /note="V -> I (in Ref. 1; CAC38026)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        861
FT                   /note="R -> Q (in Ref. 1; CAC38026)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   872 AA;  98110 MW;  D25E7A6C16CEEF4F CRC64;
     MLCDNLENWC LRMSDRMWAR QRFITQGCIE RGRLKASAES ESKVILYRAP LGYGKSVQVA
     FEAGTQGREE GGVAYINTRS YPGSGEITDS LLAALILYQI KGREPWSVIQ SNDDIIESLR
     DTLCNAKNPI KICIDGIGEA EHGVGLVENL ICETPNNVKF YIAPSNAGAL ARLSMMAGVV
     TYGAHDLVFT EEEVCELPGM HSAKAKNVIE ATGGWPALVG LMCHTSNPNL PAATWPETRS
     YFRNNLLNAL PNNTREFICK AAMLEEISVA CYDYVYKTEE AHKEIPFINE NYALFTPTES
     SRECMVMHPV LREYLRGLFD SIQRERRSYV LKRVAFWHWR RGEYLHSINA AQEASDHSWA
     RAVSDSIILD VALRQGEIEV LRTWFEKVPV RTIKKIASLS ISYAWILYFS QQARQAEKIL
     ASSTESCSRG LDNLDEKGWR KLVDAVGKAT QDQFAQSQTL CQQWIDTFGE RNMVGKGAAL
     TCQAYIASSD RRFEDLEQLL HRGAVANQSS NQHYAFVWLK TAELQAEIFK GDIAHAMSIL
     LEANKTAEKM GVSKTFLNKM LGSLELQILH EKSPSLISYE SAEESFNFAL NYGVTDILWG
     CTQTFSSFLY QQGLRDRAMA ILEQTRIAAC ERDLPRLNML AKIQLAEFTL INDEELEPPI
     LPDESELTFL PNQNQAIRAR IALVNSMYRL RLGKQFGVAE KYAKKALQSA SAISDARTKI
     AAQYCQALAV FGLGSSKLAK RTIIDADQLT EHLSCYFTRD WIKEALMSFS PIARDLFDTL
     PESAETNATK DLEVRKEEAD ARPKLTNTQS TITIKQISLL KCVSSGMTNK EIAERLLITE
     DTVKWHLKKI FSELKVTNRV RAVSEARLRG LL