ID   ALKS_PSEPU              Reviewed;         883 AA.
AC   Q9L4M7;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=HTH-type transcriptional regulator AlkS;
GN   Name=alkS;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=P1;
RX   PubMed=11207749; DOI=10.1046/j.1462-2920.1999.00037.x;
RA   Smits T.H.M., Roethlisberger M., Witholt B., Van Beilen J.B.;
RT   "Molecular screening for alkane hydroxylase genes in Gram-negative and
RT   Gram-positive strains.";
RL   Environ. Microbiol. 1:307-317(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=P1;
RX   PubMed=11390693; DOI=10.1099/00221287-147-6-1621;
RA   Van Beilen J.B., Panke S., Lucchini S., Franchini A.G., Roethlisberger M.,
RA   Witholt B.;
RT   "Analysis of Pseudomonas putida alkane degradation gene clusters and
RT   flanking insertion sequences: evolution and regulation of the alk-genes.";
RL   Microbiology 147:1621-1630(2001).
CC   -!- FUNCTION: May act as a transcriptional regulator of AlkB.
CC       {ECO:0000250}.
CC   -!- PATHWAY: Hydrocarbon metabolism; alkane degradation.
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DR   EMBL; AJ233397; CAB69079.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9L4M7; -.
DR   SMR; Q9L4M7; -.
DR   UniPathway; UPA00191; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0043448; P:alkane catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..883
FT                   /note="HTH-type transcriptional regulator AlkS"
FT                   /id="PRO_0000392224"
FT   DOMAIN          816..881
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        840..859
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   883 AA;  99414 MW;  41C26B9BCDADB71F CRC64;
     MKIKIINNDF PVAKIGLDRI TTLVSAKVHN CIYRPRLSIA DGTAPRVCLY RAPPGYGKTV
     ALAFEWLRHR TTGRPAVWIS LRASSYSEFD ICAEIIEQLE AFELVTFSHV REGVSKPTLL
     RDLASSLWQS TSSNEIETLI CLDNINQGLG LPLLHALMEF MLETPKSIRF AVAGNTIKGF
     SRLKLAGAMQ EHTEKDLAFS ADEAVALVEA EAVLGVSEVQ IEALVQEMEG WPVLIGFLLK
     CELPAKSIST VVEIDNYFND EIFEALPERY RVFLVNSSLL DVVTPDGYNY VFKCVNAASC
     IKYLSTNYML LRHVEGEPAQ FTLHPVLRDF LQGIAWAENP AKRSYLLKRA AFWHWRRGEY
     QYAIRIALRA NDCRWAVGMS EGIILDLSFR QGEIDTLRHW LSELPVKDLH KNPIVLICFA
     WVLYFSQQSA RAEKLLKDLI TPPDKKNKWQ EKGWPQLVFA IGKATNDEML LSEELCNKWI
     SLFGDSNAVG KGAALTCLAF IFASEYRFAE LEKVLAQAQA VNKFAKQDFA FGWLYVAKLQ
     QALASGKMSW ARQLITQART DSGAQIMETA FTSKMLDALE LESNYELCRL DTSEEKFSEI
     LEFIANHGVT DVFFSVCRVV SAWRLGRNDL NGSIEILEWA KAYAAEKNLP RLEVMSQIEI
     YQRLLFQGVT YINTLQAFED RKIFSGPHSA PLKARLLLVQ SLALSRDQNF HLAAHRALLA
     IQQARKISAG QLEVRGLLYL AGAQAGGGTL KKAQHNIAYA LEMAKQLQCF QTVLDEIRLI
     KRLIPTSCEV FAAVNLDQAI GAFSLPQMVE IRKSAENKAG DFLTLKQVSV LKLVKEGCSN
     KQIATKMYVT EDAIKWHMRK IFTILNVKSR TQAIIEAERQ GVI