ID   ALL12_BLOTA             Reviewed;         144 AA.
AC   Q17282;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Major allergen Blo t 12;
DE   AltName: Allergen=Blo t 12;
DE   Flags: Precursor;
OS   Blomia tropicalis (Mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Glycyphagoidea; Echimyopodidae;
OC   Blomia.
OX   NCBI_TaxID=40697;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8939156; DOI=10.1016/s0091-6749(96)80009-1;
RA   Puerta L., Caraballo L., Fernandez-Caldas E., Avjioglu A., Marsh D.G.,
RA   Lockey R.F., Dao M.L.;
RT   "Nucleotide sequence analysis of a complementary DNA coding for a Blomia
RT   tropicalis allergen.";
RL   J. Allergy Clin. Immunol. 98:932-937(1996).
CC   -!- ALLERGEN: Causes an allergic reaction in human.
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DR   EMBL; U27479; AAA78904.1; -; mRNA.
DR   PDB; 2MFK; NMR; -; A=81-144.
DR   PDBsum; 2MFK; -.
DR   AlphaFoldDB; Q17282; -.
DR   SMR; Q17282; -.
DR   Allergome; 149; Blo t 12.
DR   Allergome; 3149; Blo t 12.0101.
DR   CAZy; CBM14; Carbohydrate-Binding Module Family 14.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002557; Chitin-bd_dom.
DR   InterPro; IPR036508; Chitin-bd_dom_sf.
DR   Pfam; PF01607; CBM_14; 1.
DR   SUPFAM; SSF57625; SSF57625; 1.
DR   PROSITE; PS50940; CHIT_BIND_II; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; Chitin-binding; Disulfide bond; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..144
FT                   /note="Major allergen Blo t 12"
FT                   /id="PRO_0000020675"
FT   DOMAIN          92..144
FT                   /note="Chitin-binding type-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00144"
FT   REGION          24..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        127..140
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00144"
FT   STRAND          80..86
FT                   /evidence="ECO:0007829|PDB:2MFK"
FT   STRAND          89..94
FT                   /evidence="ECO:0007829|PDB:2MFK"
FT   STRAND          96..102
FT                   /evidence="ECO:0007829|PDB:2MFK"
FT   STRAND          109..116
FT                   /evidence="ECO:0007829|PDB:2MFK"
FT   STRAND          119..126
FT                   /evidence="ECO:0007829|PDB:2MFK"
FT   STRAND          131..134
FT                   /evidence="ECO:0007829|PDB:2MFK"
FT   TURN            135..138
FT                   /evidence="ECO:0007829|PDB:2MFK"
FT   STRAND          139..142
FT                   /evidence="ECO:0007829|PDB:2MFK"
SQ   SEQUENCE   144 AA;  16326 MW;  D901F1DA5749F7C4 CRC64;
     MKSVLIFLVA IALFSANIVS ADEQTTRGRH TEPDDHHEKP TTQCTHEETT STQHHHEEVV
     TTQTPHHEEK TTTEETHHSD DLIVHEGGKT YHVVCHEEGP IHIQEMCNKY IICSKSGSLW
     YITVMPCSIG TKFDPISRNC VLDN