ALL13_OLEEU
ID ALL13_OLEEU Reviewed; 226 AA.
AC E3SU11;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 1.
DT 03-AUG-2022, entry version 28.
DE RecName: Full=Thaumatin-like protein;
DE AltName: Full=Endo-(1,3)-beta-glucanase {ECO:0000305|PubMed:27017426};
DE EC=3.2.1.- {ECO:0000305|PubMed:27017426};
DE AltName: Allergen=Ole e 13;
DE Flags: Precursor;
OS Olea europaea (Common olive).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Oleaceae; Oleeae; Olea.
OX NCBI_TaxID=4146;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fruit;
RA Villalba M., Alvarez E., Rodriguez R.;
RT "Characterization of Ole e 13, an allergenic thaumatin from olive fruit.
RT Cloning and recombinant production.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION, AND PROTEIN SEQUENCE OF 25-42.
RX PubMed=18354115; DOI=10.1056/nejmc0707778;
RA Palomares O., Alcantara M., Quiralte J., Villalba M., Garzon F.,
RA Rodriguez R.;
RT "Airway disease and thaumatin-like protein in an olive-oil mill worker.";
RL N. Engl. J. Med. 358:1306-1308(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, AND POLYMORPHISM.
RX PubMed=21995844; DOI=10.1021/jf203363q;
RA Esteve C., Canas B., Moreno-Gordaliza E., Del Rio C., Garcia M.C.,
RA Marina M.L.;
RT "Identification of olive (Olea europaea) pulp proteins by matrix-assisted
RT laser desorption/ionization time-of-flight mass spectrometry and nano-
RT liquid chromatography tandem mass spectrometry.";
RL J. Agric. Food Chem. 59:12093-12101(2011).
RN [4]
RP REVIEW, AND NOMENCLATURE.
RX PubMed=22385802; DOI=10.1016/j.talanta.2012.01.016;
RA Esteve C., Montealegre C., Marina M.L., Garcia M.C.;
RT "Analysis of olive allergens.";
RL Talanta 92:1-14(2012).
RN [5]
RP 3D-STRUCTURE MODELING, AND PROPOSED FUNCTION.
RX PubMed=27017426; DOI=10.1016/j.jmgm.2016.03.003;
RA Jimenez-Lopez J.C., Robles-Bolivar P., Lopez-Valverde F.J.,
RA Lima-Cabello E., Kotchoni S.O., Alche J.D.;
RT "Ole e 13 is the unique food allergen in olive: Structure-functional,
RT substrates docking, and molecular allergenicity comparative analysis.";
RL J. Mol. Graph. Model. 66:26-40(2016).
CC -!- FUNCTION: 3D-structure modeling suggests it may have endo-(1,3)-beta-
CC glucanase activity. {ECO:0000305|PubMed:27017426}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in fruits. {ECO:0000269|PubMed:21995844}.
CC -!- POLYMORPHISM: Variations in the sequences detected among olive
CC varieties and within a single variety, suggesting the presence of
CC microheterogeneity. {ECO:0000269|PubMed:21995844}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Is the only allergen
CC described until now in the olive fruit. Contains epitopes responsible
CC of cross allergenicity between food and pollen allergenic thaumatin-
CC like proteins (PubMed:27017426). {ECO:0000305|PubMed:27017426}.
CC -!- SIMILARITY: Belongs to the thaumatin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00699}.
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DR EMBL; GU084174; ACZ57583.1; -; mRNA.
DR AlphaFoldDB; E3SU11; -.
DR SMR; E3SU11; -.
DR Allergome; 12135; Ole e 13.0101.
DR Allergome; 4055; Ole e 13.
DR EnsemblPlants; OE9A044804T1; OE9A044804C1; OE9A044804.
DR Gramene; OE9A044804T1; OE9A044804C1; OE9A044804.
DR PhylomeDB; E3SU11; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR Gene3D; 2.60.110.10; -; 1.
DR InterPro; IPR037176; Osmotin/thaumatin-like_sf.
DR InterPro; IPR001938; Thaumatin.
DR InterPro; IPR017949; Thaumatin_CS.
DR PANTHER; PTHR31048; PTHR31048; 1.
DR Pfam; PF00314; Thaumatin; 1.
DR PIRSF; PIRSF002703; Thaumatin; 1.
DR PRINTS; PR00347; THAUMATIN.
DR SMART; SM00205; THN; 1.
DR SUPFAM; SSF49870; SSF49870; 1.
DR PROSITE; PS00316; THAUMATIN_1; 1.
DR PROSITE; PS51367; THAUMATIN_2; 1.
PE 1: Evidence at protein level;
KW Allergen; Direct protein sequencing; Disulfide bond; Hydrolase;
KW Pathogenesis-related protein; Plant defense; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..226
FT /note="Thaumatin-like protein"
FT /id="PRO_0000421085"
FT DISULFID 33..225
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000305|PubMed:27017426"
FT DISULFID 74..84
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000305|PubMed:27017426"
FT DISULFID 89..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000305|PubMed:27017426"
FT DISULFID 140..214
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000305|PubMed:27017426"
FT DISULFID 145..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000305|PubMed:27017426"
FT DISULFID 153..163
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000305|PubMed:27017426"
FT DISULFID 167..176
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000305|PubMed:27017426"
FT DISULFID 177..184
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000305|PubMed:27017426"
SQ SEQUENCE 226 AA; 24727 MW; B2B7E563BD989FF8 CRC64;
MNFSKNLPLL VSLWAITFFA YTHAATFDIV NQCTYTVWAA ASPGGGRRLD QGQSWNINVA
PGTTQARIWG RTNCNFDANG RGQCETGDCN GLLECQGYGR PPNTLAEFAL NQPNNLDFVD
ISNVDGFNIP LEFSPTTNVC RRLVCNAPIV QQCPSELRTP GGCNNPCTVF NTNEYCCTNG
PGSCGPTPLS RFFKERCPDA YSYPQDDPTS LFTCPAGTNY RVVFCP
