ID   ALL1_CALVO              Reviewed;          16 AA.
AC   P41839;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Callatostatin-1;
DE   AltName: Full=Leu-callatostatin-1;
DE   Contains:
DE     RecName: Full=Callatostatin-2;
DE     AltName: Full=Leu-callatostatin-2;
DE   Contains:
DE     RecName: Full=Callatostatin-3;
DE     AltName: Full=Leu-callatostatin-3;
OS   Calliphora vomitoria (Blue bottle fly) (Musca vomitoria).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Calliphorinae; Calliphora.
OX   NCBI_TaxID=27454;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT LEU-16.
RC   TISSUE=Brain, Head, and Thoracic ganglion;
RX   PubMed=8460157; DOI=10.1073/pnas.90.6.2456;
RA   Duve H., Johnsen A.H., Scott A.G., Yu C.G., Yagi K.J., Tobe S.S.,
RA   Thorpe A.;
RT   "Callatostatins: neuropeptides from the blowfly Calliphora vomitoria with
RT   sequence homology to cockroach allatostatins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2456-2460(1993).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=8020069; DOI=10.1007/bf00306122;
RA   Duve H., Thorpe A.;
RT   "Distribution and functional significance of Leu-callatostatins in the
RT   blowfly Calliphora vomitoria.";
RL   Cell Tissue Res. 276:367-379(1994).
CC   -!- FUNCTION: May act as a neurotransmitter or neuromodulator and play a
CC       role in the integration of information within the brain. May be
CC       involved in the control of visceral muscles due to its ability to
CC       behave as potent inhibitors of peristaltic movements. May also fulfill
CC       a neurohormonal role on muscles of the gut and heart.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain, subesophageal ganglion, retrocerebral
CC       complex, thoracico-abdominal ganglion, peripheral neurosecretory system
CC       and intestine.
CC   -!- SIMILARITY: Belongs to the allatostatin family. {ECO:0000305}.
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DR   PIR; A47393; A47393.
DR   AlphaFoldDB; P41839; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Secreted.
FT   PEPTIDE         1..16
FT                   /note="Callatostatin-1"
FT                   /evidence="ECO:0000269|PubMed:8460157"
FT                   /id="PRO_0000001178"
FT   PEPTIDE         3..16
FT                   /note="Callatostatin-2"
FT                   /evidence="ECO:0000269|PubMed:8460157"
FT                   /id="PRO_0000001179"
FT   PEPTIDE         9..16
FT                   /note="Callatostatin-3"
FT                   /evidence="ECO:0000269|PubMed:8460157"
FT                   /id="PRO_0000001180"
FT   MOD_RES         16
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:8460157"
SQ   SEQUENCE   16 AA;  1907 MW;  A435B68C26EC3D09 CRC64;
     DPLNEERRAN RYGFGL