ID   ALL1_CANLF              Reviewed;         174 AA.
AC   O18873;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Major allergen Can f 1;
DE   AltName: Full=Allergen Dog 1;
DE   AltName: Allergen=Can f 1;
DE   Flags: Precursor;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=9497502; DOI=10.1046/j.1365-2567.1997.00386.x;
RA   Konieczny A., Morgenstern J.P., Bizinkauskas C.B., Lilley C.H.,
RA   Brauer A.W., Bond J.F., Aalberse R.C., Wallner B.P., Kasaian M.T.;
RT   "The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin
RT   proteins: cloning and immunological characterization of the recombinant
RT   forms.";
RL   Immunology 92:577-586(1997).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Tongue epithelial tissue.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000269|PubMed:9497502}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; AF027177; AAC48794.1; -; mRNA.
DR   RefSeq; NP_001003190.1; NM_001003190.1.
DR   PDB; 7DRU; X-ray; 2.50 A; A/B/C/D/E/F/G=19-174.
DR   PDBsum; 7DRU; -.
DR   AlphaFoldDB; O18873; -.
DR   SMR; O18873; -.
DR   STRING; 9615.ENSCAFP00000038987; -.
DR   Allergome; 174; Can f 1.
DR   Allergome; 3169; Can f 1.0101.
DR   PaxDb; O18873; -.
DR   PRIDE; O18873; -.
DR   ABCD; O18873; 1 sequenced antibody.
DR   GeneID; 403830; -.
DR   KEGG; cfa:403830; -.
DR   CTD; 29989; -.
DR   eggNOG; ENOG502S22P; Eukaryota.
DR   OrthoDB; 1450978at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002450; von_Ebner_gland.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01175; VNEBNERGLAND.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..174
FT                   /note="Major allergen Can f 1"
FT                   /id="PRO_0000017980"
FT   CARBOHYD        80
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        78..169
FT                   /evidence="ECO:0000250"
FT   STRAND          33..44
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   STRAND          51..53
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   STRAND          56..61
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   HELIX           62..64
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   STRAND          65..74
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   STRAND          77..87
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   STRAND          93..96
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   STRAND          101..107
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   STRAND          113..120
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   STRAND          127..136
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   HELIX           141..152
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   TURN            153..155
FT                   /evidence="ECO:0007829|PDB:7DRU"
FT   STRAND          160..162
FT                   /evidence="ECO:0007829|PDB:7DRU"
SQ   SEQUENCE   174 AA;  19248 MW;  091A3025660806D5 CRC64;
     MKTLLLTIGF SLIAILQAQD TPALGKDTVA VSGKWYLKAM TADQEVPEKP DSVTPMILKA
     QKGGNLEAKI TMLTNGQCQN ITVVLHKTSE PGKYTAYEGQ RVVFIQPSPV RDHYILYCEG
     ELHGRQIRMA KLLGRDPEQS QEALEDFREF SRAKGLNQEI LELAQSETCS PGGQ