ID   ALL2L_IXORI             Reviewed;         144 AA.
AC   A1EA99;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Mite group 2 allergen-like Ixo r 2 {ECO:0000305};
DE   AltName: Full=Der-p2 allergen-like protein {ECO:0000303|PubMed:20388233};
DE   Flags: Precursor;
OS   Ixodes ricinus (Common tick) (Acarus ricinus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=34613 {ECO:0000312|EMBL:ABL61513.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], 3D-STRUCTURE MODELING, FUNCTION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=20388233; DOI=10.1017/s0031182009992083;
RA   Horackova J., Rudenko N., Golovchenko M., Grubhoffer L.;
RT   "Der-p2 (Dermatophagoides pteronyssinus) allergen-like protein from the
RT   hard tick Ixodes ricinus - a novel member of ML (MD-2-related lipid-
RT   recognition) domain protein family.";
RL   Parasitology 137:1139-1149(2010).
CC   -!- FUNCTION: Binds human IgE in vitro, and may neutralize IgE antibodies
CC       present in blood from repeatedly tick-bitten people. Does not have
CC       antimicrobial activity against E.coli or M.luteus.
CC       {ECO:0000269|PubMed:20388233}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in gut and hemolymph. Not expressed in
CC       salivary glands, ovarium or Malpighian tubes.
CC       {ECO:0000269|PubMed:20388233}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in response to bloodmeal throughout all
CC       developmental stages including larva, nymph and adult. Slightly
CC       expressed in unfed ticks. The expression starts to increase on the
CC       first day of feeding and reaches the maximum on the third day. The
CC       level remains stable until full engorgement.
CC       {ECO:0000269|PubMed:20388233}.
CC   -!- INDUCTION: By bloodmeal. {ECO:0000269|PubMed:20388233}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; EF116564; ABL61513.1; -; mRNA.
DR   AlphaFoldDB; A1EA99; -.
DR   SMR; A1EA99; -.
DR   Allergome; 3555; Ixo r 2.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..144
FT                   /note="Mite group 2 allergen-like Ixo r 2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5002634786"
FT   DISULFID        26..136
FT                   /evidence="ECO:0000250|UniProtKB:Q00855"
FT   DISULFID        40..45
FT                   /evidence="ECO:0000250|UniProtKB:Q00855"
FT   DISULFID        91..97
FT                   /evidence="ECO:0000250|UniProtKB:Q00855"
SQ   SEQUENCE   144 AA;  15580 MW;  5F6B0431957F4080 CRC64;
     MFRYLVFLLI VGAVSCQRRK AVYKPCGGSG KLISVEVEPC DSDPCVFKKG TDVKVHVTMV
     ADQDSDTATL DARVKVFGFQ MPVPGIETDL CKGTVECPVI KGRKYSVTAI FPVPSLMSLK
     TEVTFKVIGD KGLSVCGQSD IVIE