ALL2_ASPFU
ID ALL2_ASPFU Reviewed; 310 AA.
AC P79017; Q09015; Q4WPK4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Major allergen Asp f 2;
DE AltName: Full=Allergen Asp f II;
DE AltName: Allergen=Asp f 2;
DE Flags: Precursor;
GN ORFNames=AFUA_4G09580;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 42202 / AF-102 / Ag 507;
RX PubMed=9784519; DOI=10.1128/iai.66.11.5175-5182.1998;
RA Banerjee B., Greenberger P.A., Fink J.N., Kurup V.P.;
RT "Immunological characterization of Asp f 2, a major allergen from
RT Aspergillus fumigatus associated with allergic bronchopulmonary
RT aspergillosis.";
RL Infect. Immun. 66:5175-5182(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 61-310.
RC STRAIN=ATCC 42202 / AF-102 / Ag 507;
RX PubMed=9273358; DOI=10.1016/s0022-2143(96)90093-1;
RA Banerjee B., Kurup V.P., Phadnis S., Greenberger P.A., Fink J.N.;
RT "Molecular cloning and expression of a recombinant Aspergillus fumigatus
RT protein Asp f II with significant immunoglobulin E reactivity in allergic
RT bronchopulmonary aspergillosis.";
RL J. Lab. Clin. Med. 127:253-262(1996).
CC -!- SUBCELLULAR LOCATION: Secreted. Note=Cell-associated.
CC -!- ALLERGEN: Causes an allergic reaction in human. Associated with
CC allergic bronchopulmonary aspergillosis.
CC -!- SIMILARITY: Belongs to the ZPS1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL89830.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; U56938; AAC69357.1; -; Genomic_DNA.
DR EMBL; AAHF01000005; EAL89830.1; ALT_SEQ; Genomic_DNA.
DR EMBL; U20722; AAB07620.1; -; mRNA.
DR RefSeq; XP_751868.1; XM_746775.1.
DR AlphaFoldDB; P79017; -.
DR STRING; 746128.CADAFUBP00006491; -.
DR Allergome; 3115; Asp f 2.0101.
DR Allergome; 71; Asp f 2.
DR GeneID; 3509208; -.
DR KEGG; afm:AFUA_4G09580; -.
DR eggNOG; ENOG502RTN8; Eukaryota.
DR HOGENOM; CLU_048223_0_0_1; -.
DR InParanoid; P79017; -.
DR OrthoDB; 1207536at2759; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0009277; C:fungal-type cell wall; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR CDD; cd11307; M35_Asp_f2_like; 1.
DR Gene3D; 3.40.390.10; -; 1.
DR InterPro; IPR029482; HRXXH.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR039124; PRA1-like.
DR PANTHER; PTHR39399; PTHR39399; 1.
DR Pfam; PF13933; HRXXH; 1.
PE 1: Evidence at protein level;
KW Allergen; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..310
FT /note="Major allergen Asp f 2"
FT /id="PRO_0000041748"
FT REGION 247..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 216
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 61..64
FT /note="RRQI -> SARD (in Ref. 3; AAB07620)"
FT /evidence="ECO:0000305"
FT CONFLICT 227..228
FT /note="LQ -> FE (in Ref. 1; AAC69357 and 3; AAB07620)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 32838 MW; 4736C6F9DD44387A CRC64;
MAALLRLAVL LPLAAPLVAT LPTSPVPIAA RATPHEPVFF SWDAGAVTSF PIHSSCNATQ
RRQIEAGLNE AVELARHAKA HILRWGNESE IYRKYFGNRP TMEAVGAYDV IVNGDKANVL
FRCDNPDGNC ALEGWGGHWR GANATSETVI CDRSYTTRRW LVSMCSQGYT VAGSETNTFW
ASDLMHRLYH VPAVGQGWVD HFADGYDEVI ALAKSNGTES THDSEALQYF ALEAYAFDIA
APGVGCAGES HGPDQGHDTG SASAPASTST SSSSSGSGSG ATTTPTDSPS ATIDVPSNCH
THEGGQLHCT
