ID   3NO41_BUNMU             Reviewed;          84 AA.
AC   Q70WS8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Neurotoxin BM10-1-like {ECO:0000303|PubMed:14559085};
DE            Short=BM10-1l {ECO:0000303|PubMed:14559085};
DE   Flags: Precursor;
OS   Bungarus multicinctus (Many-banded krait).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX   NCBI_TaxID=8616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=14559085; DOI=10.1016/s0041-0101(03)00151-x;
RA   Chang L.-S., Chung C., Liou J.-C., Chang C.-W., Yang C.-C.;
RT   "Novel neurotoxins from Taiwan banded krait (Bungarus multicinctus) venom:
RT   purification, characterization and gene organization.";
RL   Toxicon 42:323-330(2003).
CC   -!- FUNCTION: Binds and inhibits muscular and neuronal nicotinic
CC       acetylcholine receptors (nAChR). {ECO:0000250|UniProtKB:P81783}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. Orphan group IV sub-subfamily. {ECO:0000305}.
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DR   EMBL; AJ515364; CAD56381.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q70WS8; -.
DR   SMR; Q70WS8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   3: Inferred from homology;
KW   Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..84
FT                   /note="Neurotoxin BM10-1-like"
FT                   /id="PRO_0000251733"
FT   DISULFID        24..47
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        27..32
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        40..64
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        68..76
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        77..82
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
SQ   SEQUENCE   84 AA;  9539 MW;  96C40056CA759877 CRC64;
     MKTLLLTLVV VTIVCLDLGY TMKCKICHFD TCRAGELKVC ASGEKYCFKE SWREAREVKI
     IRGCSSSCPE KKNVFCCSTN DCNW