ALL2_DERPT
ID ALL2_DERPT Reviewed; 146 AA.
AC P49278;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Mite group 2 allergen Der p 2;
DE AltName: Full=Allergen Der p II;
DE AltName: Full=DPX;
DE AltName: Allergen=Der p 2;
DE Flags: Precursor;
GN Name=DERP2;
OS Dermatophagoides pteronyssinus (European house dust mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC Pyroglyphidae; Dermatophagoidinae; Dermatophagoides.
OX NCBI_TaxID=6956;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2341191; DOI=10.1159/000235101;
RA Chua K.Y., Doyle C.R., Simpson R.J., Turner K.J., Stewart G.A.,
RA Thomas W.R.;
RT "Isolation of cDNA coding for the major mite allergen Der p II by IgE
RT plaque immunoassay.";
RL Int. Arch. Allergy Appl. Immunol. 91:118-123(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS.
RX PubMed=11398075; DOI=10.1067/mai.2001.114652;
RA Smith W.-A., Hales B.J., Jarnicki A.G., Thomas W.R.;
RT "Allergens of wild house dust mites: environmental Der p 1 and Der p 2
RT sequence polymorphisms.";
RL J. Allergy Clin. Immunol. 107:985-992(2001).
RN [3]
RP PROTEIN SEQUENCE OF 18-57.
RX PubMed=2732406; DOI=10.1016/0091-6749(89)90447-8;
RA Heymann P.W., Chapman M.D., Aalberse R.C., Fox J.W., Platts-Mills T.A.E.;
RT "Antigenic and structural analysis of group II allergens (Der f II and Der
RT p II) from house dust mites (Dermatophagoides spp).";
RL J. Allergy Clin. Immunol. 83:1055-1067(1989).
RN [4]
RP STRUCTURE BY NMR.
RX PubMed=9737847; DOI=10.1021/bi980578+;
RA Mueller G.A., Benjamin D.C., Rule G.S.;
RT "Tertiary structure of the major house dust mite allergen Der p 2:
RT sequential and structural homologies.";
RL Biochemistry 37:12707-12714(1998).
CC -!- INTERACTION:
CC P49278; Q9Y6Y9: LY96; Xeno; NbExp=2; IntAct=EBI-15745025, EBI-1539247;
CC P49278; O00206-1: TLR4; Xeno; NbExp=3; IntAct=EBI-15745025, EBI-15745059;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR EMBL; AF276239; AAF86462.1; -; mRNA.
DR PIR; A60381; A60381.
DR PDB; 1A9V; NMR; -; A=19-146.
DR PDB; 1KTJ; X-ray; 2.15 A; A/B=18-146.
DR PDB; 6OY4; X-ray; 2.45 A; A=18-146.
DR PDBsum; 1A9V; -.
DR PDBsum; 1KTJ; -.
DR PDBsum; 6OY4; -.
DR AlphaFoldDB; P49278; -.
DR SMR; P49278; -.
DR DIP; DIP-59729N; -.
DR IntAct; P49278; 3.
DR Allergome; 316; Der p 2.
DR ABCD; P49278; 16 sequenced antibodies.
DR EvolutionaryTrace; P49278; -.
DR Proteomes; UP000515146; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306; PTHR11306; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Allergen; Direct protein sequencing; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000269|PubMed:2732406"
FT CHAIN 18..146
FT /note="Mite group 2 allergen Der p 2"
FT /id="PRO_0000019861"
FT DISULFID 25..136
FT DISULFID 38..44
FT DISULFID 90..95
FT VARIANT 39
FT /note="H -> A"
FT VARIANT 40
FT /note="G -> L"
FT VARIANT 44
FT /note="C -> N"
FT VARIANT 47
FT /note="H -> S"
FT VARIANT 49
FT /note="G -> T"
FT VARIANT 56
FT /note="A -> Y"
FT VARIANT 57
FT /note="V -> L"
FT VARIANT 61
FT /note="N -> L"
FT VARIANT 64
FT /note="T -> S"
FT VARIANT 75
FT /note="I -> Y"
FT VARIANT 78
FT /note="L -> C"
FT VARIANT 81
FT /note="D -> V"
FT VARIANT 95
FT /note="C -> P"
FT VARIANT 98
FT /note="V -> T"
FT VARIANT 108
FT /note="T -> V"
FT VARIANT 111
FT /note="V -> L"
FT VARIANT 114
FT /note="I -> N"
FT VARIANT 115
FT /note="A -> T"
FT VARIANT 116
FT /note="P -> A"
FT VARIANT 118
FT /note="S -> A"
FT VARIANT 127
FT /note="V -> L"
FT VARIANT 128
FT /note="M -> L"
FT VARIANT 131
FT /note="D -> N"
FT VARIANT 133
FT /note="V -> A"
FT VARIANT 144
FT /note="I -> L"
FT STRAND 26..28
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 30..34
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 40..42
FT /evidence="ECO:0007829|PDB:1A9V"
FT STRAND 44..47
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 50..59
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 68..75
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 78..80
FT /evidence="ECO:0007829|PDB:1KTJ"
FT HELIX 89..91
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 95..97
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 102..110
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 121..129
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 132..139
FT /evidence="ECO:0007829|PDB:1KTJ"
FT STRAND 142..145
FT /evidence="ECO:0007829|PDB:1KTJ"
SQ SEQUENCE 146 AA; 15999 MW; 591B2FA7FD26D3AF CRC64;
MMYKILCLSL LVAAVARDQV DVKDCANHEI KKVLVPGCHG SEPCIIHRGK PFQLEAVFEA
NQNTKTAKIE IKASIDGLEV DVPGIDPNAC HYMKCPLVKG QQYDIKYTWN VPKIAPKSEN
VVVTVKVMGD DGVLACAIAT HAKIRD
