ID   ALL2_EURMA              Reviewed;         145 AA.
AC   Q9TZZ2; O96430;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Mite group 2 allergen Eur m 2;
DE   AltName: Allergen=Eur m 2;
DE   Flags: Precursor;
GN   Name=EURM2;
OS   Euroglyphus maynei (Mayne's house dust mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC   Pyroglyphidae; Pyroglyphinae; Euroglyphus.
OX   NCBI_TaxID=6958;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9925958; DOI=10.1159/000024026;
RA   Smith W., Mills K., Hazell L., Hart B.J., Thomas W.;
RT   "Molecular analysis of the group 1 and 2 allergens from the house dust
RT   mite, Euroglyphus maynei.";
RL   Int. Arch. Allergy Immunol. 118:15-22(1999).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- POLYMORPHISM: The sequence shown is that of isoform Eur m 2.0101.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC       allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; AF047613; AAC82349.1; -; mRNA.
DR   EMBL; AF047614; AAC82350.1; -; mRNA.
DR   AlphaFoldDB; Q9TZZ2; -.
DR   SMR; Q9TZZ2; -.
DR   Allergome; 340; Eur m 2.
DR   Allergome; 341; Eur m 2.0101.
DR   Allergome; 342; Eur m 2.0102.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   1: Evidence at protein level;
KW   Allergen; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..145
FT                   /note="Mite group 2 allergen Eur m 2"
FT                   /id="PRO_0000019862"
FT   DISULFID        24..135
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..43
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..94
FT                   /evidence="ECO:0000250"
FT   VARIANT         21
FT                   /note="I -> V (in Eur m 2 0102)"
SQ   SEQUENCE   145 AA;  15747 MW;  6655B16C8503A565 CRC64;
     MYKILCLSLL VAAVAADQVD IKDCANHEIK KVMVPGCKGS EPCVIHRGTA FQLEAVFDAN
     QNSNAAKIEI KATIDGVEID VPGIDNNLCH FMKCPLVKGQ EYDIKYTWNV PRIAPKSENV
     VVTVKLLGDN GVLACAIATH AKIRD