ALL2_LEPDS
ID ALL2_LEPDS Reviewed; 141 AA.
AC P80384; Q8MYK7; Q8MYK8;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Mite group 2 allergen Lep d 2;
DE AltName: Full=Allergen Lep d 1;
DE AltName: Full=Allergen Lep d I;
DE AltName: Allergen=Lep d 2;
DE Flags: Precursor;
OS Lepidoglyphus destructor (Storage mite) (Glycyphagus destructor).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Glycyphagoidea; Glycyphagidae;
OC Lepidoglyphus.
OX NCBI_TaxID=36936;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (LEP D 2.0101 AND LEP D 2.0201).
RX PubMed=7649288; DOI=10.1016/0014-5793(95)98164-e;
RA Schmidt M., van der Ploeg I., Olsson S., van Hage-Hamsten M.;
RT "cDNA analysis of the mite allergen Lep d 1 identifies two different
RT isoallergens and variants.";
RL FEBS Lett. 370:11-14(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE (LEP D 2.0103 AND LEP D 2.0203).
RX PubMed=12581204; DOI=10.1046/j.1432-1033.2003.03412.x;
RA Kaiser L., Gafvelin G., Johansson E., van Hage-Hamsten M., Rasool O.;
RT "Lep d 2 polymorphisms in wild and cultured Lepidoglyphus destructor
RT mites.";
RL Eur. J. Biochem. 270:646-653(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 44-141, AND PROTEIN SEQUENCE OF 17-140.
RX PubMed=7925475; DOI=10.1111/j.1432-1033.1994.00093.x;
RA Varela J., Ventas P., Carreira J., Barbas J.A., Gimenez-Gallego G.,
RA Polo F.;
RT "Primary structure of Lep d I, the main Lepidoglyphus destructor
RT allergen.";
RL Eur. J. Biochem. 225:93-98(1994).
RN [4]
RP PROTEIN SEQUENCE OF 17-45.
RA Muthiah R., Miller M., Kagen S.;
RT "Barn allergy: isolation and characterization of the major allergens of
RT storagemites: L. destructor.";
RL J. Allergy Clin. Immunol. 87:326-326(1991).
RN [5]
RP PROTEIN SEQUENCE OF 17-34.
RX PubMed=1355192; DOI=10.1016/0140-6736(92)92152-6;
RA van Hage-Hamsten M., Bergman T., Johansson E., Persson B., Joernvall H.,
RA Haerfast B., Johansson S.G.O.;
RT "N-terminal aminoacid sequence of principal allergen of storage mite
RT Lepidoglyphus destructor.";
RL Lancet 340:614-614(1992).
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- POLYMORPHISM: The sequence shown is that of isoform Lep d 2.0101.
CC -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR EMBL; X83875; CAA58755.1; -; mRNA.
DR EMBL; X83876; CAA58756.1; -; mRNA.
DR EMBL; X89014; CAA61419.1; -; mRNA.
DR EMBL; AJ487972; CAD32313.1; -; Genomic_DNA.
DR EMBL; AJ487973; CAD32314.1; -; Genomic_DNA.
DR EMBL; X81399; CAA57160.1; -; mRNA.
DR PIR; S66499; S66499.
DR PIR; S66500; S66500.
DR AlphaFoldDB; P80384; -.
DR SMR; P80384; -.
DR Allergome; 439; Lep d 2.
DR Allergome; 440; Lep d 2.0101.
DR Allergome; 441; Lep d 2.0201.
DR Allergome; 442; Lep d 2.0102.
DR Allergome; 443; Lep d 2.0202.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306; PTHR11306; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 1: Evidence at protein level;
KW Allergen; Direct protein sequencing; Disulfide bond; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000269|PubMed:1355192,
FT ECO:0000269|PubMed:7925475, ECO:0000269|Ref.4"
FT CHAIN 17..141
FT /note="Mite group 2 allergen Lep d 2"
FT /id="PRO_0000019863"
FT REPEAT 64..65
FT /note="1"
FT REPEAT 68..69
FT /note="2"
FT REPEAT 72..73
FT /note="3"
FT REGION 64..73
FT /note="3 X 2 AA repeats of K-V"
FT DISULFID 24..133
FT /evidence="ECO:0000250"
FT DISULFID 37..42
FT /evidence="ECO:0000250"
FT DISULFID 88..93
FT /evidence="ECO:0000250"
FT VARIANT 35
FT /note="T -> S (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 48
FT /note="E -> Q (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 53
FT /note="E -> D (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 63
FT /note="A -> N (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 71
FT /note="A -> T (in Lep d 2.0103)"
FT VARIANT 90
FT /note="F -> V (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 91
FT /note="I -> L (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 95
FT /note="V -> I (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 104
FT /note="I -> N (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 106
FT /note="S -> G (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 107
FT /note="G -> M (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 116
FT /note="V -> I (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 118
FT /note="A -> V (in Lep d 2.0203)"
FT VARIANT 125
FT /note="I -> V (in Lep d 2.0201 and Lep d 2.0203)"
FT VARIANT 136
FT /note="V -> I (in Lep d 2.0201 and Lep d 2.0203)"
FT CONFLICT 26
FT /note="H -> K (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="T -> K (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 141 AA; 14773 MW; 9AC96F74D6826FA4 CRC64;
MMKFIALFAL VAVASAGKMT FKDCGHGEVT ELDITGCSGD TCVIHRGEKM TLEAKFAANQ
DTAKVTIKVL AKVAGTTIQV PGLETDGCKF IKCPVKKGEA LDFIYSGTIP AITPKVKADV
TAELIGDHGV MACGTVHGQV E
