ID   GATC_RAT                Reviewed;         155 AA.
AC   D3ZY68;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03149};
DE            Short=Glu-AdT subunit C {ECO:0000255|HAMAP-Rule:MF_03149};
DE            EC=6.3.5.- {ECO:0000255|HAMAP-Rule:MF_03149};
DE   Flags: Precursor;
GN   Name=Gatc;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Allows the formation of correctly charged Gln-tRNA(Gln)
CC       through the transamidation of misacylated Glu-tRNA(Gln) in the
CC       mitochondria. The reaction takes place in the presence of glutamine and
CC       ATP through an activated gamma-phospho-Glu-tRNA(Gln).
CC       {ECO:0000255|HAMAP-Rule:MF_03149}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) +
CC         L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate;
CC         Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359,
CC         ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_03149};
CC   -!- SUBUNIT: Subunit of the heterotrimeric GatCAB amidotransferase (AdT)
CC       complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_03149}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03149}.
CC   -!- SIMILARITY: Belongs to the GatC family. {ECO:0000255|HAMAP-
CC       Rule:MF_03149}.
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DR   EMBL; CH473973; EDM13888.1; -; Genomic_DNA.
DR   RefSeq; NP_001101809.1; NM_001108339.1.
DR   AlphaFoldDB; D3ZY68; -.
DR   STRING; 10116.ENSRNOP00000001536; -.
DR   jPOST; D3ZY68; -.
DR   PaxDb; D3ZY68; -.
DR   PeptideAtlas; D3ZY68; -.
DR   PRIDE; D3ZY68; -.
DR   Ensembl; ENSRNOT00000070868; ENSRNOP00000063917; ENSRNOG00000045621.
DR   GeneID; 360821; -.
DR   KEGG; rno:360821; -.
DR   UCSC; RGD:1309698; rat.
DR   CTD; 283459; -.
DR   RGD; 1309698; Gatc.
DR   VEuPathDB; HostDB:ENSRNOG00000001163; -.
DR   eggNOG; KOG4247; Eukaryota.
DR   HOGENOM; CLU_105899_0_2_1; -.
DR   InParanoid; D3ZY68; -.
DR   OMA; CTEELLH; -.
DR   OrthoDB; 1496962at2759; -.
DR   PhylomeDB; D3ZY68; -.
DR   TreeFam; TF106133; -.
DR   PRO; PR:D3ZY68; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Proteomes; UP000234681; Chromosome 12.
DR   Bgee; ENSRNOG00000001161; Expressed in quadriceps femoris and 19 other tissues.
DR   Genevisible; D3ZY68; RN.
DR   GO; GO:0030956; C:glutamyl-tRNA(Gln) amidotransferase complex; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0050567; F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity; ISO:RGD.
DR   GO; GO:0070681; P:glutaminyl-tRNAGln biosynthesis via transamidation; ISO:RGD.
DR   GO; GO:0032543; P:mitochondrial translation; ISO:RGD.
DR   GO; GO:0006450; P:regulation of translational fidelity; IEA:InterPro.
DR   HAMAP; MF_00122; GatC; 1.
DR   InterPro; IPR003837; Asp/Glu-ADT_csu.
DR   InterPro; IPR036113; Asp/Glu-ADT_sf_sub_c.
DR   PANTHER; PTHR15004; PTHR15004; 1.
DR   Pfam; PF02686; Glu-tRNAGln; 1.
DR   SUPFAM; SSF141000; SSF141000; 1.
DR   TIGRFAMs; TIGR00135; gatC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Mitochondrion; Nucleotide-binding;
KW   Protein biosynthesis; Reference proteome; Transit peptide.
FT   TRANSIT         1..20
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03149"
FT   CHAIN           21..155
FT                   /note="Glutamyl-tRNA(Gln) amidotransferase subunit C,
FT                   mitochondrial"
FT                   /id="PRO_0000413290"
FT   REGION          19..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   155 AA;  16833 MW;  41491BA2DB7336A7 CRC64;
     MWAQAARVQF RAPLDRGRSF ASKVGPRGKV QAADPKTQAP RLVPEGTDRV SAAVVEHLER
     LALVNFSSRE AVDRLEKAVA FADQLHAVDT DGVEPLESVL EDRCLYLRSD KVAEGGCAEE
     LLQNSNHVVE EYFVAPPGNI PLPDMVGKVP SSTAE