ID   ALL2_PSOOV              Reviewed;         143 AA.
AC   Q965E2;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Mite group 2 allergen Pso o 2;
DE   AltName: Full=Allergen Pso o A;
DE   AltName: Allergen=Pso o 2;
DE   Flags: Precursor;
GN   Name=ALLA;
OS   Psoroptes ovis (Sheep scab mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC   Psoroptidae; Psoroptes.
OX   NCBI_TaxID=83912;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11931040; DOI=10.1603/0022-2585-39.2.384;
RA   Temeyer K.B., Soileau L.C., Pruett J.H.;
RT   "Cloning and sequence analysis of a cDNA encoding Pso o II, a mite group II
RT   allergen of the sheep scab mite (Acari: Psoroptidae).";
RL   J. Med. Entomol. 39:384-391(2002).
RN   [2]
RP   PROTEIN SEQUENCE OF N-TERMINUS.
RX   PubMed=10534947; DOI=10.1093/jmedent/36.5.544;
RA   Pruett J.H.;
RT   "Identification and purification of a 16-kDa allergen from Psoroptes ovis
RT   (Acarina: Psoroptidae).";
RL   J. Med. Entomol. 36:544-550(1999).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC       allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF187083; AAK61827.1; -; mRNA.
DR   AlphaFoldDB; Q965E2; -.
DR   SMR; Q965E2; -.
DR   Allergome; 606; Pso o 2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000269|PubMed:10534947"
FT   CHAIN           18..143
FT                   /note="Mite group 2 allergen Pso o 2"
FT                   /id="PRO_0000019864"
FT   DISULFID        25..134
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..43
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..94
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   143 AA;  15212 MW;  AF03533059DA838D CRC64;
     MMKTLVVLAI TLAVVSAGKV KFQDCGKGEV ESLEVEGCSG DYCVIHKGKK LDLAISVTSN
     QDSANLKLDI VADINGVQIE VPGVDHDGCH YVKCPIKKGQ HFDVKYTYSI PAILPTTKAK
     IIAKIIGDKG LGGCIVINGE IQD