ID   ALL2_TYRPU              Reviewed;         141 AA.
AC   O02380;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Mite group 2 allergen Tyr p 2 {ECO:0000303|PubMed:9492316};
DE   AltName: Allergen=Tyr p 2.0101 {ECO:0000305};
DE   Flags: Precursor;
OS   Tyrophagus putrescentiae (Mold mite) (Acarus putrescentiae).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Acaroidea; Acaridae; Tyrophaginae;
OC   Tyrophagus.
OX   NCBI_TaxID=59818;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 16-22, AND ALLERGEN.
RX   PubMed=9492316; DOI=10.1046/j.1432-1327.1998.2510443.x;
RA   Eriksson T.L.J., Johansson E., Whitley P., Schmidt M., Elsayed S.,
RA   van Hage-Hamsten M.;
RT   "Cloning and characterisation of a group II allergen from the dust mite
RT   Tyrophagus putrescentiae.";
RL   Eur. J. Biochem. 251:443-447(1998).
RN   [2]
RP   ALLERGEN.
RX   PubMed=20197679; DOI=10.1159/000288290;
RA   Liao E.C., Ho C.M., Tsai J.J.;
RT   "Prevalence of Tyrophagus putrescentiae hypersensitivity in subjects over
RT   70 years of age in a veterans' nursing home in Taiwan.";
RL   Int. Arch. Allergy Immunol. 152:368-377(2010).
RN   [3]
RP   ALLERGEN, AND 3D-STRUCTURE MODELING.
RX   PubMed=20683648; DOI=10.1007/s10875-010-9446-x;
RA   Liao E.C., Ho C.M., Lin M.Y., Tsai J.J.;
RT   "Dermatophagoides pteronyssinus and Tyrophagus putrescentiae allergy in
RT   allergic rhinitis caused by cross-reactivity not dual-sensitization.";
RL   J. Clin. Immunol. 30:830-839(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE of
CC       patients allergic to storage mite T.putrescentiae (PubMed:9492316,
CC       PubMed:20197679, PubMed:20683648). Binds to IgE in 53% of the 44
CC       elderly patients (aged 70-90) tested (PubMed:20197679). Binds to IgE in
CC       73% of the 22 young adult rhinitis patients tested allergic to mites
CC       (both T.putrescentiae and D.pteronyssinus) (PubMed:20683648). Common
CC       symptoms of mite allergy are bronchial asthma, allergic rhinitis and
CC       conjunctivitis (Probable). {ECO:0000269|PubMed:20197679,
CC       ECO:0000269|PubMed:20683648, ECO:0000269|PubMed:9492316, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y12690; CAA73221.1; -; mRNA.
DR   AlphaFoldDB; O02380; -.
DR   SMR; O02380; -.
DR   Allergome; 3511; Tyr p 2.0101.
DR   Allergome; 657; Tyr p 2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000269|PubMed:9492316"
FT   CHAIN           16..141
FT                   /note="Mite group 2 allergen Tyr p 2"
FT                   /id="PRO_0000019865"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        23..132
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        87..92
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   141 AA;  14852 MW;  38EF9520010A04C1 CRC64;
     MKFLILFALV AVAAAGQVKF TDCGKKEIAS VAVDGCEGDL CVIHKSKPVH VIAEFTANQD
     TCKIEVKVTG QLNGLEVPIP GIETDGCKVL KCPLKKGTKY TMNYSVNVPS VVPNIKTVVK
     LLATGEHGVL ACGAVNTDVK P