ALL3_AEDAE
ID ALL3_AEDAE Reviewed; 273 AA.
AC O01949; Q1HRK2; Q1HRK5;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=30 kDa salivary gland allergen Aed a 3;
DE AltName: Allergen=Aed a 3;
DE Flags: Precursor;
GN ORFNames=AAEL010235;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=Rockefeller; TISSUE=Salivary gland;
RA Xu W., Simons F.E.R., Peng Z.;
RT "Molecular cloning and characterization of the gene encoding a 30 kDa
RT salivary allergen of mosquito Aedes aegypti.";
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=Black-eyed Liverpool; TISSUE=Salivary gland;
RX PubMed=17204158; DOI=10.1186/1471-2164-8-6;
RA Ribeiro J.M.C., Arca B., Lombardo F., Calvo E., Phan V.M., Chandra P.K.,
RA Wikel S.K.;
RT "An annotated catalogue of salivary gland transcripts in the adult female
RT mosquito, Aedes aegypti.";
RL BMC Genomics 8:6-6(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- INTERACTION:
CC O01949; P02452: COL1A1; Xeno; NbExp=5; IntAct=EBI-7685554, EBI-982999;
CC O01949; P02461: COL3A1; Xeno; NbExp=2; IntAct=EBI-7685554, EBI-2431491;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=2;
CC IsoId=O01949-1; Sequence=Displayed;
CC Name=1;
CC IsoId=O01949-2; Sequence=VSP_034685, VSP_034686;
CC Name=3;
CC IsoId=O01949-3; Sequence=VSP_034685, VSP_034687;
CC -!- TISSUE SPECIFICITY: Adult female salivary gland.
CC -!- ALLERGEN: Causes an allergic reaction in human.
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DR EMBL; AF001927; AAB58417.1; -; mRNA.
DR EMBL; DQ440089; ABF18122.1; -; mRNA.
DR EMBL; DQ440092; ABF18125.1; -; mRNA.
DR EMBL; CH477649; EAT37812.1; -; Genomic_DNA.
DR RefSeq; XP_001660691.1; XM_001660641.1.
DR AlphaFoldDB; O01949; -.
DR SMR; O01949; -.
DR IntAct; O01949; 2.
DR MINT; O01949; -.
DR STRING; 7159.AAEL010235-PA; -.
DR Allergome; 3054; Aed a 3.0101.
DR Allergome; 5; Aed a 3.
DR GeneID; 5580040; -.
DR KEGG; aag:5580040; -.
DR VEuPathDB; VectorBase:AAEL010235; -.
DR eggNOG; ENOG502TC7R; Eukaryota.
DR HOGENOM; CLU_1103566_0_0_1; -.
DR InParanoid; O01949; -.
DR OMA; TYRQVHK; -.
DR OrthoDB; 1789136at2759; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR017262; Salivary_gland_allergen_Aed3.
DR PIRSF; PIRSF037682; Salivary_gland_allergen_Aed3; 1.
PE 1: Evidence at protein level;
KW Allergen; Alternative splicing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..273
FT /note="30 kDa salivary gland allergen Aed a 3"
FT /id="PRO_0000020676"
FT REGION 20..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..64
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..141
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 35..44
FT /note="Missing (in isoform 1 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:17204158, ECO:0000303|Ref.1"
FT /id="VSP_034685"
FT VAR_SEQ 85..94
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_034686"
FT VAR_SEQ 85..89
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17204158"
FT /id="VSP_034687"
FT CONFLICT 69
FT /note="K -> E (in Ref. 1; AAB58417 and 2; ABF18125)"
FT /evidence="ECO:0000305"
FT CONFLICT 143
FT /note="D -> A (in Ref. 1; AAB58417 and 2; ABF18125)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 29155 MW; C827EFA0FE76E721 CRC64;
MKPLVKLFLL FCLVGIVLSR PMPEDEEPVA EGGDDDASGE SEGEEETTDD AGGDGGEEEN
EGEEHAGDKD AGGEDTGKEE NTGHDDAGEE DAGEEDAGEE DAGEEDAGEE DAEKEEGEKE
DAGDDAGSDD GEEDSTGGDE GEDNAEDSKG SEKNDPADTY RQVVALLDKD TKVDHIQSEY
LRSALNNDLQ SEVRVPVVEA IGRIGDYSKI QGCFKSMGKD VKKVISEEEK KFKSCMSKKK
SEYQCSEDSF AAAKSKLSPI TSKIKSCVSS KGR
