ALL3_OLEEU
ID ALL3_OLEEU Reviewed; 84 AA.
AC O81092;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Polcalcin Ole e 3;
DE AltName: Full=Calcium-binding pollen allergen Ole e 3;
DE AltName: Allergen=Ole e 3;
GN Name=OLE3;
OS Olea europaea (Common olive).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Oleaceae; Oleeae; Olea.
OX NCBI_TaxID=4146;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pollen;
RX PubMed=9874211; DOI=10.1046/j.1432-1327.1998.2580454.x;
RA Ledesma A., Villalba M., Batanero E., Rodriguez R.;
RT "Molecular cloning and expression of active Ole e 3, a major allergen from
RT olive-tree pollen and member of a novel family of Ca2+-binding proteins
RT (polcalcins) involved in allergy.";
RL Eur. J. Biochem. 258:454-459(1998).
RN [2]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Picual;
RA Alche J.D., Cismondi I.D., Castro A.J., Hamman-Khalifa A.M.,
RA Rodriguez-Garcia M.I.;
RT "Temporal and spatial gene expression of Ole e 3 allergen in olive (Olea
RT europaea L.) pollen.";
RL Acta Biol. Crac. Ser. Bot. 45:89-95(2003).
RN [3]
RP REVIEW, AND NOMENCLATURE.
RX PubMed=22385802; DOI=10.1016/j.talanta.2012.01.016;
RA Esteve C., Montealegre C., Marina M.L., Garcia M.C.;
RT "Analysis of olive allergens.";
RL Talanta 92:1-14(2012).
CC -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|Ref.2}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in mature pollen.
CC {ECO:0000269|Ref.2}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
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DR EMBL; AF015810; AAD05375.1; -; mRNA.
DR AlphaFoldDB; O81092; -.
DR SMR; O81092; -.
DR Allergome; 3384; Ole e 3.0101.
DR Allergome; 491; Ole e 3.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Allergen; Calcium; Membrane; Metal-binding; Repeat.
FT CHAIN 1..84
FT /note="Polcalcin Ole e 3"
FT /id="PRO_0000073674"
FT DOMAIN 6..40
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 41..76
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 19
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 21
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 23
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 25
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 30
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 58
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 65
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 84 AA; 9356 MW; BC3B3DE011D409D0 CRC64;
MADDPQEVAE HERIFKRFDA NGDGKISSSE LGETLKTLGS VTPEEIQRMM AEIDTDGDGF
ISFEEFTVFA RANRGLVKDV AKIF
