ID   ALL4_ASPFU              Reviewed;         322 AA.
AC   O60024; Q4WHX8;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Allergen Asp f 4;
DE   AltName: Allergen=Asp f 4;
DE   Flags: Precursor;
GN   ORFNames=AFUA_2G03830;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 37-322.
RC   STRAIN=ATCC 42202 / AF-102 / Ag 507;
RA   Hemmann S., Nikolaizik W.H., Schoeni M.H., Blaser K., Crameri R.;
RT   "Diagnosis of allergic bronchopulmonary aspergillosis in patients with
RT   cystic fibrosis by IgE-specific serology with recombinant Aspergillus
RT   fumigatus allergens.";
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
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DR   EMBL; AAHF01000008; EAL87477.1; -; Genomic_DNA.
DR   EMBL; AJ001732; CAA04959.1; -; mRNA.
DR   RefSeq; XP_749515.1; XM_744422.1.
DR   AlphaFoldDB; O60024; -.
DR   STRING; 746128.CADAFUBP00002039; -.
DR   Allergome; 3122; Asp f 4.0101.
DR   Allergome; 74; Asp f 4.
DR   EnsemblFungi; EAL87477; EAL87477; AFUA_2G03830.
DR   GeneID; 3506748; -.
DR   KEGG; afm:AFUA_2G03830; -.
DR   VEuPathDB; FungiDB:Afu2g03830; -.
DR   eggNOG; ENOG502SN6Y; Eukaryota.
DR   HOGENOM; CLU_043430_1_0_1; -.
DR   InParanoid; O60024; -.
DR   OMA; ASQYKHV; -.
DR   OrthoDB; 1476063at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0019863; F:IgE binding; IDA:AspGD.
DR   InterPro; IPR038903; Allergen_Asp_f_4.
DR   PANTHER; PTHR42039; PTHR42039; 1.
PE   1: Evidence at protein level;
KW   Allergen; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..322
FT                   /note="Allergen Asp f 4"
FT                   /id="PRO_0000043341"
FT   REGION          80..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        37
FT                   /note="R -> G (in Ref. 2; CAA04959)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        247
FT                   /note="Q -> H (in Ref. 2; CAA04959)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   322 AA;  34085 MW;  7EE283EB0E444EF0 CRC64;
     MQLKNSMLLL TALAAGSSVA RLHGHERRHL HHAGEKREVG DTVYATINGV LVSWINEWSG
     EAKTSDAPVS QATPVSNAVA AAAAASTPEP SSSHSDSSSS SGVSADWTNT PAEGEYCTDG
     FGGRTEPSGS GIFYKGNVGK PWGSNIIEVS PENAKKYKHV AQFVGSDTDP WTVVFWNKIG
     PDGGLTGWYG NSALTLHLEA GETKYVAFDE NSQGAWGAAK GDELPKDQFG GYSCTWGEFD
     FDSKINQGWS GWDVSAIQAE NAHHEVQGMK ICNHAGELCS IISHGLSKVI DAYTADLAGV
     DGIGGKVVPG PTRLVVNLDY KE