ALL4_CALVO
ID ALL4_CALVO Reviewed; 8 AA.
AC P41840;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 02-JUN-2021, entry version 47.
DE RecName: Full=Callatostatin-4;
DE AltName: Full=Leu-callatostatin-4;
OS Calliphora vomitoria (Blue bottle fly) (Musca vomitoria).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Calliphorinae; Calliphora.
OX NCBI_TaxID=27454;
RN [1]
RP PROTEIN SEQUENCE, AND AMIDATION AT LEU-8.
RC TISSUE=Thoracic ganglion;
RX PubMed=8460157; DOI=10.1073/pnas.90.6.2456;
RA Duve H., Johnsen A.H., Scott A.G., Yu C.G., Yagi K.J., Tobe S.S.,
RA Thorpe A.;
RT "Callatostatins: neuropeptides from the blowfly Calliphora vomitoria with
RT sequence homology to cockroach allatostatins.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:2456-2460(1993).
RN [2]
RP CHARACTERIZATION.
RX PubMed=8020069; DOI=10.1007/bf00306122;
RA Duve H., Thorpe A.;
RT "Distribution and functional significance of Leu-callatostatins in the
RT blowfly Calliphora vomitoria.";
RL Cell Tissue Res. 276:367-379(1994).
CC -!- FUNCTION: May act as a neurotransmitter or neuromodulator and play a
CC role in the integration of information within the brain. May be
CC involved in the control of visceral muscles due to its ability to
CC behave as potent inhibitors of peristaltic movements. May also fulfill
CC a neurohormonal role on muscles of the gut and heart.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Brain, subesophageal ganglion, retrocerebral
CC complex, thoracico-abdominal ganglion, peripheral neurosecretory system
CC and intestine.
CC -!- SIMILARITY: Belongs to the allatostatin family. {ECO:0000305}.
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DR PIR; D47393; D47393.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT PEPTIDE 1..8
FT /note="Callatostatin-4"
FT /id="PRO_0000043457"
FT MOD_RES 8
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8460157"
FT UNSURE 1
FT /note="D or N"
SQ SEQUENCE 8 AA; 954 MW; D32879D5AB47740A CRC64;
DRPYSFGL