GATD1_DANRE
ID GATD1_DANRE Reviewed; 242 AA.
AC Q1L8G7; Q1RM13;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=GATA zinc finger domain-containing protein 1;
GN Name=gatad1; ORFNames=si:dkey-231l1.7, zgc:136582;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of some chromatin complex recruited to chromatin
CC sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for
CC trimethylated form (H3K4me3). {ECO:0000250|UniProtKB:Q8WUU5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WUU5}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR786578; CAK10740.1; -; Genomic_DNA.
DR EMBL; BC115186; AAI15187.1; -; mRNA.
DR RefSeq; NP_001035454.1; NM_001040364.1.
DR AlphaFoldDB; Q1L8G7; -.
DR STRING; 7955.ENSDARP00000051711; -.
DR PaxDb; Q1L8G7; -.
DR Ensembl; ENSDART00000051712; ENSDARP00000051711; ENSDARG00000027612.
DR GeneID; 678617; -.
DR KEGG; dre:678617; -.
DR CTD; 57798; -.
DR ZFIN; ZDB-GENE-050629-1; gatad1.
DR eggNOG; ENOG502QUY5; Eukaryota.
DR GeneTree; ENSGT00390000018554; -.
DR HOGENOM; CLU_070432_0_0_1; -.
DR InParanoid; Q1L8G7; -.
DR OMA; FYKGVYF; -.
DR OrthoDB; 1259563at2759; -.
DR PhylomeDB; Q1L8G7; -.
DR TreeFam; TF325354; -.
DR PRO; PR:Q1L8G7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000027612; Expressed in testis and 24 other tissues.
DR GO; GO:0031674; C:I band; IDA:ZFIN.
DR GO; GO:0005634; C:nucleus; IDA:ZFIN.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR039050; GATAD1.
DR InterPro; IPR000679; Znf_GATA.
DR PANTHER; PTHR13340; PTHR13340; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..242
FT /note="GATA zinc finger domain-containing protein 1"
FT /id="PRO_0000288911"
FT ZN_FING 9..33
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 44..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 141
FT /note="P -> L (in Ref. 2; AAI15187)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="S -> N (in Ref. 2; AAI15187)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 242 AA; 26708 MW; B975762B965C7BA0 CRC64;
MPLGLKPCCA VCKTQSSSMW KKGNQGEILC NGCTGKAVSS GGSGASASST IQQNNGGGKQ
SKQEIHRRSA RLRSTKYKAP ASEKKVSTKG KGRRHIFKLK NPIKAPESVS TIITSESMFY
KGIYYQIGDV IKVIDEDDGK PYYAQIRGFV QDQYCEKSAA LTWLIPTQAS PRDRFDPSTY
IVGPEEDLPR KMEYLEFVCH APSEYFKSRS CPFPTLPVRP EKGYVWTHIG PTPAVAIKET
VG
