GATD1_MOUSE
ID GATD1_MOUSE Reviewed; 266 AA.
AC Q920S3; Q8VCQ2; Q9CSG2;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=GATA zinc finger domain-containing protein 1;
DE AltName: Full=Ocular development-associated gene protein;
GN Name=Gatad1; Synonyms=Odag;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Brain;
RX PubMed=12062807; DOI=10.1016/s0378-1119(02)00563-2;
RA Tsuruga T., Kanamoto T., Kato T., Yamashita H., Miyagawa K., Mishima H.K.;
RT "Ocular development-associated gene (ODAG), a novel gene highly expressed
RT in ocular development.";
RL Gene 290:125-130(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=21965549; DOI=10.1161/circgenetics.111.961052;
RA Theis J.L., Sharpe K.M., Matsumoto M.E., Chai H.S., Nair A.A., Theis J.D.,
RA de Andrade M., Wieben E.D., Michels V.V., Olson T.M.;
RT "Homozygosity mapping and exome sequencing reveal GATAD1 mutation in
RT autosomal recessive dilated cardiomyopathy.";
RL Circ. Cardiovasc. Genet. 4:585-594(2011).
CC -!- FUNCTION: Component of some chromatin complex recruited to chromatin
CC sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for
CC trimethylated form (H3K4me3). {ECO:0000250|UniProtKB:Q8WUU5}.
CC -!- SUBUNIT: Component of a chromatin complex, at least composed of KDM5A,
CC GATAD1 and EMSY. {ECO:0000250|UniProtKB:Q8WUU5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WUU5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q920S3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q920S3-2; Sequence=VSP_025823, VSP_025824;
CC -!- TISSUE SPECIFICITY: Expressed in the eye (lens, ciliary body, retina,
CC sclera and conjunctiva) at postnatal day 2 and 10. Not detected
CC anywhere at postnatal day 14. {ECO:0000269|PubMed:12062807}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryo at 13 dpc onwards. Expressed
CC in embryonic heart at all stages of development.
CC {ECO:0000269|PubMed:12062807, ECO:0000269|PubMed:21965549}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB28550.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB047921; BAB69047.1; -; mRNA.
DR EMBL; AK012921; BAB28550.2; ALT_SEQ; mRNA.
DR EMBL; BC019449; AAH19449.1; -; mRNA.
DR CCDS; CCDS19066.1; -. [Q920S3-1]
DR RefSeq; NP_080309.2; NM_026033.2. [Q920S3-1]
DR AlphaFoldDB; Q920S3; -.
DR STRING; 10090.ENSMUSP00000007559; -.
DR iPTMnet; Q920S3; -.
DR PhosphoSitePlus; Q920S3; -.
DR EPD; Q920S3; -.
DR jPOST; Q920S3; -.
DR MaxQB; Q920S3; -.
DR PaxDb; Q920S3; -.
DR PeptideAtlas; Q920S3; -.
DR PRIDE; Q920S3; -.
DR ProteomicsDB; 272932; -. [Q920S3-1]
DR ProteomicsDB; 272933; -. [Q920S3-2]
DR Antibodypedia; 1808; 205 antibodies from 22 providers.
DR Ensembl; ENSMUST00000007559; ENSMUSP00000007559; ENSMUSG00000007415. [Q920S3-1]
DR Ensembl; ENSMUST00000119783; ENSMUSP00000113271; ENSMUSG00000007415. [Q920S3-2]
DR GeneID; 67210; -.
DR KEGG; mmu:67210; -.
DR UCSC; uc008whh.2; mouse. [Q920S3-1]
DR UCSC; uc008whi.2; mouse. [Q920S3-2]
DR CTD; 57798; -.
DR MGI; MGI:1914460; Gatad1.
DR VEuPathDB; HostDB:ENSMUSG00000007415; -.
DR eggNOG; ENOG502QUY5; Eukaryota.
DR GeneTree; ENSGT00390000018554; -.
DR HOGENOM; CLU_070432_0_0_1; -.
DR InParanoid; Q920S3; -.
DR OMA; FYKGVYF; -.
DR OrthoDB; 1259563at2759; -.
DR PhylomeDB; Q920S3; -.
DR TreeFam; TF325354; -.
DR BioGRID-ORCS; 67210; 9 hits in 75 CRISPR screens.
DR ChiTaRS; Gatad1; mouse.
DR PRO; PR:Q920S3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q920S3; protein.
DR Bgee; ENSMUSG00000007415; Expressed in embryonic post-anal tail and 258 other tissues.
DR ExpressionAtlas; Q920S3; baseline and differential.
DR Genevisible; Q920S3; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; ISO:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR039050; GATAD1.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR13340; PTHR13340; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..266
FT /note="GATA zinc finger domain-containing protein 1"
FT /id="PRO_0000288910"
FT ZN_FING 9..33
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 59..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 259
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8WUU5"
FT VAR_SEQ 205..218
FT /note="PEEDLPRKMEYLEF -> EAQHLRFTSFFSAL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025823"
FT VAR_SEQ 219..266
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025824"
FT CONFLICT 60
FT /note="T -> A (in Ref. 1; BAB69047)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="D -> G (in Ref. 2; BAB28550)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 266 AA; 28535 MW; 23A09267763A37CE CRC64;
MPLGLKPTCS MCKTTSSSMW KKSPQGEILC HHCTGRGGGG AGVAGGTGGG GGGGGGFGTT
TFATTSAGPS QSNGGGGGKQ SKQEIHRRSA RLRNTKYKSA PAAEKKVSTK GKGRRHIFKL
KNPIKAPESV STIVTAESIF YKGVYYQIGD VVSVIDEQDG KPYYAQIRGF IQDQYCEKSA
ALTWLIPTLA SPRDQFDPAS YIIGPEEDLP RKMEYLEFVC HAPSEYFKSR SSPFPTVPTR
PEKGYIWTHV GPTPAITIKE TVANHL
