ID   ALL4_FELCA              Reviewed;         186 AA.
AC   Q5VFH6;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Allergen Fel d 4;
DE   AltName: Allergen=Fel d 4;
DE   Flags: Precursor;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   TISSUE=Submandibular gland;
RX   PubMed=15544598; DOI=10.1111/j.1365-2222.2004.02090.x;
RA   Smith W.-A., Butler A.J.L., Hazell L.A., Chapman M.D., Pomes A.,
RA   Nickels D.G., Thomas W.R.;
RT   "Fel d 4, a cat lipocalin allergen.";
RL   Clin. Exp. Allergy 34:1732-1738(2004).
RN   [2]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=20478258; DOI=10.1016/j.cell.2010.03.037;
RA   Papes F., Logan D.W., Stowers L.;
RT   "The vomeronasal organ mediates interspecies defensive behaviors through
RT   detection of protein pheromone homologs.";
RL   Cell 141:692-703(2010).
CC   -!- FUNCTION: May be a pheromone carrier. Acts as a kairomone, detected by
CC       the prey vomeronasal organ and inducing fear reactions in mice.
CC       {ECO:0000269|PubMed:20478258}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Abundant in urine (at protein level).
CC       {ECO:0000269|PubMed:20478258}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC       {ECO:0000269|PubMed:15544598}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY497902; AAS77253.1; -; mRNA.
DR   RefSeq; NP_001009233.1; NM_001009233.1.
DR   AlphaFoldDB; Q5VFH6; -.
DR   SMR; Q5VFH6; -.
DR   STRING; 9685.ENSFCAP00000024901; -.
DR   Allergome; 1326; Fel d 4.
DR   Allergome; 3281; Fel d 4.0101.
DR   GeneID; 493739; -.
DR   KEGG; fca:493739; -.
DR   eggNOG; ENOG502SWRK; Eukaryota.
DR   OrthoDB; 1475169at2759; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002971; Maj_urinary.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01221; MAJORURINARY.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   1: Evidence at protein level;
KW   Allergen; Behavior; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal; Transport.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..186
FT                   /note="Allergen Fel d 4"
FT                   /id="PRO_0000041864"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        81..171
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   186 AA;  21308 MW;  683213698B3CC48E CRC64;
     MKLLLLCLGL ILVCAHEEEN VVRSNIDISK ISGEWYSILL ASDVKEKIEE NGSMRVFVEH
     IKALDNSSLS FVFHTKENGK CTEIFLVADK TKDGVYTVVY DGYNVFSIVE TVYDEYILLH
     LLNFDKTRPF QLVEFYAREP DVSQKLKEKF VKYCQEHGIV NILDLTEVDR CLQARGSEVA
     QDSSVE