ID   ALL5_APIGR              Reviewed;          86 AA.
AC   P81943;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2003, sequence version 3.
DT   11-DEC-2019, entry version 46.
DE   RecName: Full=Allergen Api g 5;
DE   AltName: Allergen=Api g 5;
DE   Flags: Fragments;
OS   Apium graveolens (Celery).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Apiales; Apiaceae; Apioideae; apioid superclade;
OC   Apieae; Apium.
OX   NCBI_TaxID=4045;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 1-18, AND ALLERGEN.
RC   TISSUE=Tuber {ECO:0000269|PubMed:10718855};
RX   PubMed=10718855; DOI=10.1046/j.1365-2222.2000.00773.x;
RA   Ganglberger E., Radauer C., Grimm R., Hoffmann-Sommergruber K.,
RA   Breiteneder H., Scheiner O., Jensen-Jarolim E.;
RT   "N-terminal sequences of high molecular weight allergens from celery
RT   tuber.";
RL   Clin. Exp. Allergy 30:566-570(2000).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 19-86, SEQUENCE REVISION, GLYCOSYLATION, AND ALLERGEN.
RC   TISSUE=Tuber {ECO:0000269|PubMed:12958180};
RX   PubMed=12958180; DOI=10.1096/fj.02-0872fje;
RA   Bublin M., Radauer C., Wilson I.B.H., Kraft D., Scheiner O.,
RA   Breiteneder H., Hoffmann-Sommergruber K.;
RT   "Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein
RT   allergen from celery, are required for immunoglobulin E binding and
RT   activation of effector cells from allergic patients.";
RL   FASEB J. 17:1697-1699(2003).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000250|UniProtKB:P93479};
CC   -!- PTM: Carries MUXF and MMXF, two complex N-linked glycans with alpha-
CC       1,3-fucose and beta-1,2-xylose residues in their structures. MMXF is
CC       added to Asn-62. {ECO:0000269|PubMed:12958180}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE. The
CC       glycan moiety seems to constitute the relevant allergenic epitope.
CC       {ECO:0000269|PubMed:10718855, ECO:0000269|PubMed:12958180}.
CC   -!- SIMILARITY: Belongs to the oxygen-dependent FAD-linked oxidoreductase
CC       family. {ECO:0000255}.
CC   -!- CAUTION: The order of the peptides shown is unknown.
CC       {ECO:0000269|PubMed:12958180}.
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DR   Allergome; 3087; Api g 5.0101.
DR   Allergome; 44; Api g 5.
DR   iPTMnet; P81943; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; FAD; Flavoprotein; Glycoprotein;
KW   Oxidoreductase.
FT   CHAIN           1..>86
FT                   /note="Allergen Api g 5"
FT                   /id="PRO_0000128175"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:12958180"
FT   NON_CONS        22..23
FT                   /evidence="ECO:0000303|PubMed:12958180"
FT   NON_CONS        52..53
FT                   /evidence="ECO:0000303|PubMed:12958180"
FT   NON_CONS        76..77
FT                   /evidence="ECO:0000303|PubMed:12958180"
FT   NON_TER         86
FT                   /evidence="ECO:0000303|PubMed:12958180"
SQ   SEQUENCE   86 AA;  9441 MW;  09F5C64FA7ACD452 CRC64;
     LPNPSGFVTC LSSISKSVYT PAINLKAVIA DPVAKTAVVQ AGATLGEVYY XIIYARVLWV
     GNTTQKLEWI RSLHDYQSSF FPFFSA