ID   ALL5_CALVO              Reviewed;           8 AA.
AC   P41841;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Callatostatin-5;
DE   AltName: Full=Met-callatostatin-1;
DE   AltName: Full=[Hyp3]Met-callatostatin;
OS   Calliphora vomitoria (Blue bottle fly) (Musca vomitoria).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Calliphorinae; Calliphora.
OX   NCBI_TaxID=27454;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT MET-8.
RX   PubMed=8460157; DOI=10.1073/pnas.90.6.2456;
RA   Duve H., Johnsen A.H., Scott A.G., Yu C.G., Yagi K.J., Tobe S.S.,
RA   Thorpe A.;
RT   "Callatostatins: neuropeptides from the blowfly Calliphora vomitoria with
RT   sequence homology to cockroach allatostatins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2456-2460(1993).
RN   [2]
RP   CHARACTERIZATION, AND HYDROXYLATION AT PRO-3.
RC   TISSUE=Head;
RX   PubMed=8063725; DOI=10.1016/s0021-9258(17)31929-4;
RA   Duve H., Johnsen A.H., Scott A.G., East P., Thorpe A.;
RT   "[Hyp3]Met-callatostatin. Identification and biological properties of a
RT   novel neuropeptide from the blowfly Calliphora vomitoria.";
RL   J. Biol. Chem. 269:21059-21066(1994).
CC   -!- FUNCTION: May act as a neurotransmitter or neuromodulator and play a
CC       role in the integration of information within the brain. May be
CC       involved in the control of visceral muscles due to its ability to
CC       behave as potent inhibitors of peristaltic movements. May also fulfill
CC       a neurohormonal role on muscles of the gut and heart.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Neurons within brain and abdominal ganglion.
CC   -!- SIMILARITY: Belongs to the allatostatin family. {ECO:0000305}.
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DR   PIR; E47393; E47393.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hydroxylation; Neuropeptide;
KW   Secreted.
FT   PEPTIDE         1..8
FT                   /note="Callatostatin-5"
FT                   /id="PRO_0000043458"
FT   MOD_RES         3
FT                   /note="Hydroxyproline; partial"
FT                   /evidence="ECO:0000269|PubMed:8063725"
FT   MOD_RES         8
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:8460157"
SQ   SEQUENCE   8 AA;  883 MW;  7D9879CABB477768 CRC64;
     GPPYDFGM