ID   ALL5_HEVBR              Reviewed;         151 AA.
AC   Q39967;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Major latex allergen Hev b 5;
DE   AltName: Allergen=Hev b 5;
OS   Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Micrandreae;
OC   Hevea.
OX   NCBI_TaxID=3981;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. RRIM 600; TISSUE=Latex;
RX   PubMed=8810306; DOI=10.1074/jbc.271.41.25394;
RA   Slater J.E., Vedvick T., Arthur-Smith A., Trybul D.E., Kekwick R.G.O.;
RT   "Identification, cloning, and sequence of a major allergen (Hev b 5) from
RT   natural rubber latex (Hevea brasiliensis).";
RL   J. Biol. Chem. 271:25394-25399(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND MASS
RP   SPECTROMETRY.
RC   STRAIN=cv. RRIM 600; TISSUE=Latex;
RX   PubMed=8810305; DOI=10.1074/jbc.271.41.25389;
RA   Akasawa A., Hsieh L.-S., Martin B.M., Liu T., Lin Y.;
RT   "A novel acidic allergen, Hev b 5, in latex. Purification, cloning and
RT   characterization.";
RL   J. Biol. Chem. 271:25389-25393(1996).
CC   -!- PTM: The N-terminus is blocked.
CC   -!- MASS SPECTROMETRY: Mass=16001.2; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:8810305};
CC   -!- ALLERGEN: Causes an allergic reaction in human. Major latex allergen, a
CC       major cause of anaphylaxis in susceptible individuals, especially
CC       health care workers. 92% of health care workers with latex allergy have
CC       IgE specific to the Hev b 5 protein.
CC   -!- SIMILARITY: To kiwi fruit protein PKIWI501. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U42640; AAC49447.1; -; mRNA.
DR   EMBL; U51631; AAC49448.1; -; mRNA.
DR   PIR; T10768; T10768.
DR   AlphaFoldDB; Q39967; -.
DR   Allergome; 3316; Hev b 5.0101.
DR   Allergome; 389; Hev b 5.
PE   1: Evidence at protein level;
KW   Acetylation; Allergen; Direct protein sequencing.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..151
FT                   /note="Major latex allergen Hev b 5"
FT                   /id="PRO_0000064561"
FT   REGION          1..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   151 AA;  16090 MW;  1E5E1B73E9715CD5 CRC64;
     MASVEVESAA TALPKNETPE VTKAEETKTE EPAAPPASEQ ETADATPEKE EPTAAPAEPE
     APAPETEKAE EVEKIEKTEE PAPEADQTTP EEKPAEPEPV AEEEPKHETK ETETEAPAAP
     AEGEKPAEEE KPITEAAETA TTEVPVEKTE E