GATR_ECOLI
ID GATR_ECOLI Reviewed; 112 AA.
AC P36930; P76408; P76409;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2017, sequence version 3.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Putative galactitol utilization operon repressor;
GN Name=gatR; OrderedLocusNames=b4498, JW5340/JW2074; ORFNames=b2087/b2090;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND IDENTIFICATION.
RC STRAIN=EC3132;
RX PubMed=7772602; DOI=10.1016/0167-4781(95)00053-j;
RA Nobelmann B., Lengeler J.W.;
RT "Sequence of the gat operon for galactitol utilization from a wild-type
RT strain EC3132 of Escherichia coli.";
RL Biochim. Biophys. Acta 1262:69-72(1995).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-112.
RC STRAIN=K12 / W3110;
RA Umeda M., Ohtsubo E.;
RT "Nucleotide sequences flanking each of the five IS3 elements in Escherichia
RT coli.";
RL Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Repressor of the gat operon for galacticol transport and
CC metabolism. In K12 strains the operon is constitutively expressed
CC because this gene is inactive (PubMed:7772602).
CC {ECO:0000305|PubMed:7772602}.
CC -!- CAUTION: Could be the product of a pseudogene, in E.coli K12, an
CC insertion sequence (IS3E) is inserted in the gatR gene in position 102.
CC {ECO:0000305}.
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DR EMBL; U00096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP009048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X79837; CAA56232.1; -; Genomic_DNA.
DR EMBL; D12598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P36930; -.
DR IntAct; P36930; 8.
DR PRIDE; P36930; -.
DR EchoBASE; EB2081; -.
DR InParanoid; P36930; -.
DR PhylomeDB; P36930; -.
DR PRO; PR:P36930; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001034; DeoR_HTH.
DR InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF08220; HTH_DeoR; 1.
DR PRINTS; PR00037; HTHLACR.
DR SMART; SM00420; HTH_DEOR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00894; HTH_DEOR_1; 1.
DR PROSITE; PS51000; HTH_DEOR_2; 1.
PE 5: Uncertain;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..112
FT /note="Putative galactitol utilization operon repressor"
FT /id="PRO_0000050250"
FT DOMAIN 5..60
FT /note="HTH deoR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT DNA_BIND 22..41
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT CONFLICT 103..112
FT /note="DPTHVIWTQA -> TVILDSGSTTMLIAED (in Ref. 4;
FT CAA56232)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 112 AA; 12403 MW; 810985B7D0A57BA6 CRC64;
MTMNSFERRN KIIQLVNEQG TVLVQDLAGV FAASEATIRA DLRFLEQKGV VTRFHGGAAK
IMSGNSETET QEVGFKERFQ LASAPKNRIA QAAVKMIHEG MTDPTHVIWT QA
