ID   ALL6_OLEEU              Reviewed;          50 AA.
AC   O24172; Q5DTB8; Q84UC2;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Major pollen allergen Ole e 6;
DE   AltName: Allergen=Ole e 6;
GN   Name=OLE6;
OS   Olea europaea (Common olive).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Oleaceae; Oleeae; Olea.
OX   NCBI_TaxID=4146;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-24, TISSUE SPECIFICITY,
RP   AND ALLERGENICITY.
RC   TISSUE=Pollen;
RX   PubMed=9237648; DOI=10.1016/s0014-5793(97)00582-6;
RA   Batanero E., Ledesma A., Villalba M., Rodriguez R.;
RT   "Purification, amino acid sequence and immunological characterization of
RT   Ole e 6, a cysteine-enriched allergen from olive tree pollen.";
RL   FEBS Lett. 410:293-296(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 8-50.
RC   TISSUE=Mesocarp;
RA   Hamman Khalifa A., Alche J., Rodriguez Garcia M.;
RT   "Temporal and spatial gene expression of Ole e 6 allergen in olive (Olea
RT   europaea L.) pollen.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-50.
RA   Hamman Khalifa A., Alche J., Rodriguez Garcia M.;
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=16689547; DOI=10.1021/ac0600508;
RA   Napoli A., Aiello D., Di Donna L., Sajjad A., Perri E., Sindona G.;
RT   "Profiling of hydrophilic proteins from Olea europaea olive pollen by MALDI
RT   TOF mass spectrometry.";
RL   Anal. Chem. 78:3434-3443(2006).
RN   [5]
RP   REVIEW, AND NOMENCLATURE.
RX   PubMed=22385802; DOI=10.1016/j.talanta.2012.01.016;
RA   Esteve C., Montealegre C., Marina M.L., Garcia M.C.;
RT   "Analysis of olive allergens.";
RL   Talanta 92:1-14(2012).
RN   [6]
RP   STRUCTURE BY NMR, AND DISULFIDE BONDS.
RX   PubMed=15247256; DOI=10.1074/jbc.m406045200;
RA   Trevino M.A., Garcia-Mayoral M.F., Barral P., Villalba M., Santoro J.,
RA   Rico M., Rodriguez R., Bruix M.;
RT   "NMR solution structure of Ole e 6, a major allergen from olive tree
RT   pollen.";
RL   J. Biol. Chem. 279:39035-39041(2004).
CC   -!- TISSUE SPECIFICITY: Expressed in pollen. {ECO:0000269|PubMed:9237648}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Major allergen from
CC       olive pollen. {ECO:0000269|PubMed:9237648}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U86342; AAB66909.1; -; mRNA.
DR   EMBL; AY172112; AAO33896.1; -; Genomic_DNA.
DR   EMBL; AY221958; AAO34670.1; -; mRNA.
DR   PDB; 1SS3; NMR; -; A=1-50.
DR   PDBsum; 1SS3; -.
DR   AlphaFoldDB; O24172; -.
DR   SMR; O24172; -.
DR   Allergome; 3387; Ole e 6.0101.
DR   Allergome; 494; Ole e 6.
DR   EnsemblPlants; OE9A022228T1; OE9A022228C1; OE9A022228.
DR   EnsemblPlants; Oeu029462.1; Oeu029462.1; Oeu029462.
DR   Gramene; OE9A022228T1; OE9A022228C1; OE9A022228.
DR   Gramene; Oeu029462.1; Oeu029462.1; Oeu029462.
DR   EvolutionaryTrace; O24172; -.
DR   GO; GO:0019864; F:IgG binding; IDA:CAFA.
DR   DisProt; DP00580; -.
DR   Gene3D; 1.10.287.720; -; 1.
DR   InterPro; IPR015333; Pollen_allergen_ole-e-6.
DR   InterPro; IPR036466; Pollen_allergen_ole-e-6_sf.
DR   PANTHER; PTHR35632; PTHR35632; 1.
DR   Pfam; PF09253; Ole_e_6; 1.
DR   SUPFAM; SSF111388; SSF111388; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; Direct protein sequencing; Disulfide bond.
FT   CHAIN           1..50
FT                   /note="Major pollen allergen Ole e 6"
FT                   /id="PRO_0000064562"
FT   DISULFID        8..34
FT                   /evidence="ECO:0000269|PubMed:15247256"
FT   DISULFID        12..30
FT                   /evidence="ECO:0000269|PubMed:15247256"
FT   DISULFID        16..26
FT                   /evidence="ECO:0000269|PubMed:15247256"
FT   HELIX           3..17
FT                   /evidence="ECO:0007829|PDB:1SS3"
FT   TURN            18..20
FT                   /evidence="ECO:0007829|PDB:1SS3"
FT   HELIX           23..33
FT                   /evidence="ECO:0007829|PDB:1SS3"
SQ   SEQUENCE   50 AA;  5833 MW;  DD770D3612933FB2 CRC64;
     DEAQFKECYD TCHKECSDKG NGFTFCEMKC DTDCSVKDVK EKLENYKPKN