ID   3NO52_BUNMU             Reviewed;          89 AA.
AC   Q9YGH9;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Long neurotoxin homolog NTL2;
DE   Flags: Precursor;
OS   Bungarus multicinctus (Many-banded krait).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX   NCBI_TaxID=8616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=9844743; DOI=10.1080/15216549800204362;
RA   Qian Y.-C., Fan C.-Y., Gong Y., Yang S.-L.;
RT   "cDNA cloning and sequence analysis of six neurotoxin-like proteins from
RT   Chinese continental banded krait.";
RL   Biochem. Mol. Biol. Int. 46:821-828(1998).
CC   -!- FUNCTION: Exhibits M2 muscarinic acetylcholine receptor (CHRM2)-
CC       blocking activity, but has a weak binding activity toward nicotinic
CC       AChR. Moreover, it inhibits collagen-induced platelet aggregation.
CC       {ECO:0000250|UniProtKB:Q9YGJ0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9YGJ0}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. Orphan group V sub-subfamily. {ECO:0000305}.
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DR   EMBL; AJ223251; CAA11214.1; -; mRNA.
DR   AlphaFoldDB; Q9YGH9; -.
DR   SMR; Q9YGH9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   3: Inferred from homology;
KW   Cell adhesion impairing toxin; Disulfide bond;
KW   G-protein coupled acetylcholine receptor impairing toxin;
KW   G-protein coupled receptor impairing toxin; Hemostasis impairing toxin;
KW   Neurotoxin; Platelet aggregation inhibiting toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250|UniProtKB:Q9YGJ0"
FT   CHAIN           22..89
FT                   /note="Long neurotoxin homolog NTL2"
FT                   /id="PRO_0000035427"
FT   MOTIF           54..56
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00293"
FT   DISULFID        24..45
FT                   /evidence="ECO:0000250|UniProtKB:Q9YGJ0"
FT   DISULFID        27..32
FT                   /evidence="ECO:0000250|UniProtKB:Q9YGJ0"
FT   DISULFID        38..66
FT                   /evidence="ECO:0000250|UniProtKB:Q9YGJ0"
FT   DISULFID        70..81
FT                   /evidence="ECO:0000250|UniProtKB:Q9YGJ0"
FT   DISULFID        82..87
FT                   /evidence="ECO:0000250|UniProtKB:Q9YGJ0"
SQ   SEQUENCE   89 AA;  9873 MW;  545E79D2EA56E2E5 CRC64;
     MKTLLLSLVV VIIVCLDLGY TMQCKTCSFY TCPNSETCPD GKNICVKRSW TAVRGDGPKR
     EIRRECAATC PPSKLGLTVF CCTTDNCYH