GATZ_ECO57
ID GATZ_ECO57 Reviewed; 420 AA.
AC Q8X7H4; Q7ACL2;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit GatZ;
GN Name=gatZ; OrderedLocusNames=Z3258, ECs2898;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
RG New York structural genomix research consortium (NYSGXRC);
RT "Crystal structure of putative tagatose 6-phosphate kinase.";
RL Submitted (APR-2006) to the PDB data bank.
CC -!- FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase GatYZ
CC that is required for full activity and stability of the Y subunit.
CC Could have a chaperone-like function for the proper and stable folding
CC of GatY. When expressed alone, GatZ does not show any aldolase
CC activity. Is involved in the catabolism of galactitol (By similarity).
CC {ECO:0000250}.
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2.
CC -!- SUBUNIT: Forms a complex with GatY. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GatZ/KbaZ family. GatZ subfamily.
CC {ECO:0000305}.
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DR EMBL; AE005174; AAG57152.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB36321.1; -; Genomic_DNA.
DR PIR; B90991; B90991.
DR PIR; D85836; D85836.
DR RefSeq; NP_310925.1; NC_002695.1.
DR RefSeq; WP_000853846.1; NZ_SWKA01000005.1.
DR PDB; 2FIQ; X-ray; 2.25 A; A/B/C/D=1-420.
DR PDBsum; 2FIQ; -.
DR AlphaFoldDB; Q8X7H4; -.
DR SMR; Q8X7H4; -.
DR STRING; 155864.EDL933_3164; -.
DR DNASU; 916601; -.
DR EnsemblBacteria; AAG57152; AAG57152; Z3258.
DR EnsemblBacteria; BAB36321; BAB36321; ECs_2898.
DR GeneID; 916601; -.
DR KEGG; ece:Z3258; -.
DR KEGG; ecs:ECs_2898; -.
DR PATRIC; fig|386585.9.peg.3030; -.
DR eggNOG; COG4573; Bacteria.
DR HOGENOM; CLU_053334_0_0_6; -.
DR OMA; AINAVHV; -.
DR UniPathway; UPA00704; UER00716.
DR EvolutionaryTrace; Q8X7H4; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019404; P:galactitol catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_01296; Tagatose_aldol_GatZ; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR012062; GatZ/KbaZ-like.
DR InterPro; IPR023436; TagBP_ald_GatZ.
DR Pfam; PF08013; GatZ_KbaZ-like; 1.
DR PIRSF; PIRSF009264; TagBP_ald_AgaZ; 1.
DR TIGRFAMs; TIGR02810; agaZ_gatZ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Galactitol metabolism; Reference proteome.
FT CHAIN 1..420
FT /note="D-tagatose-1,6-bisphosphate aldolase subunit GatZ"
FT /id="PRO_0000355359"
FT HELIX 2..9
FT /evidence="ECO:0007829|PDB:2FIQ"
FT STRAND 16..19
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 24..33
FT /evidence="ECO:0007829|PDB:2FIQ"
FT TURN 34..36
FT /evidence="ECO:0007829|PDB:2FIQ"
FT STRAND 41..46
FT /evidence="ECO:0007829|PDB:2FIQ"
FT TURN 47..49
FT /evidence="ECO:0007829|PDB:2FIQ"
FT TURN 55..58
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 61..75
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 79..81
FT /evidence="ECO:0007829|PDB:2FIQ"
FT STRAND 82..91
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 92..94
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 99..115
FT /evidence="ECO:0007829|PDB:2FIQ"
FT STRAND 120..123
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 138..155
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 158..163
FT /evidence="ECO:0007829|PDB:2FIQ"
FT STRAND 165..169
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 190..205
FT /evidence="ECO:0007829|PDB:2FIQ"
FT TURN 206..208
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 210..214
FT /evidence="ECO:0007829|PDB:2FIQ"
FT STRAND 216..220
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 237..240
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 241..247
FT /evidence="ECO:0007829|PDB:2FIQ"
FT STRAND 253..257
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 264..272
FT /evidence="ECO:0007829|PDB:2FIQ"
FT STRAND 275..280
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 282..302
FT /evidence="ECO:0007829|PDB:2FIQ"
FT TURN 305..307
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 311..321
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 323..325
FT /evidence="ECO:0007829|PDB:2FIQ"
FT TURN 326..329
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 334..343
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 348..351
FT /evidence="ECO:0007829|PDB:2FIQ"
FT TURN 352..354
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 356..370
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 376..382
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 384..391
FT /evidence="ECO:0007829|PDB:2FIQ"
FT HELIX 399..418
FT /evidence="ECO:0007829|PDB:2FIQ"
SQ SEQUENCE 420 AA; 47022 MW; 9E765977C05F4B6E CRC64;
MKTLIARHKA GEHIGICSVC SAHPLVIEAA LAFDRNSTRK VLIEATSNQV NQFGGYTGMT
PADFREFVFA IADKVGFARE RIILGGDHLG PNCWQQENVD AAMEKSVELV KAYVRAGFSK
IHLDASMSCA GDPIPLAPET VAERAAVLCF AAESVATDCQ REQLSYVIGT EVPVPGGEAS
AIQSVHITHV EDAANTLRTH QKAFIARGLT EALTRVIAIV VQPGVEFDHS NIIHYQPQEA
QALAQWIENT RMVYEAHSTD YQTRTAYWEL VRDHFAILKV GPALTFALRE AIFALAQIEQ
ELIAPENRSG CLAVIEEVML DEPQYWKKYY RTGFNDSLLD IRYSLSDRIR YYWPHSRIKN
SVETMMVNLQ GVDIPLGMIS QYLPKQFERI QSGELSAIPH QLIMDKIYDV LRAYRYGCAE
