ID   GATZ_ECO5E              Reviewed;         420 AA.
AC   B5YV42;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit GatZ {ECO:0000255|HAMAP-Rule:MF_01296};
GN   Name=gatZ {ECO:0000255|HAMAP-Rule:MF_01296};
GN   OrderedLocusNames=ECH74115_3074;
OS   Escherichia coli O157:H7 (strain EC4115 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=444450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC4115 / EHEC;
RX   PubMed=22135463; DOI=10.1073/pnas.1107176108;
RA   Eppinger M., Mammel M.K., Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Genomic anatomy of Escherichia coli O157:H7 outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20142-20147(2011).
CC   -!- FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase GatYZ
CC       that is required for full activity and stability of the Y subunit.
CC       Could have a chaperone-like function for the proper and stable folding
CC       of GatY. When expressed alone, GatZ does not show any aldolase
CC       activity. Is involved in the catabolism of galactitol.
CC       {ECO:0000255|HAMAP-Rule:MF_01296}.
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_01296}.
CC   -!- SUBUNIT: Forms a complex with GatY. {ECO:0000255|HAMAP-Rule:MF_01296}.
CC   -!- SIMILARITY: Belongs to the GatZ/KbaZ family. GatZ subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01296}.
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DR   EMBL; CP001164; ACI39792.1; -; Genomic_DNA.
DR   RefSeq; WP_000853846.1; NC_011353.1.
DR   AlphaFoldDB; B5YV42; -.
DR   SMR; B5YV42; -.
DR   KEGG; ecf:ECH74115_3074; -.
DR   HOGENOM; CLU_053334_0_0_6; -.
DR   OMA; AINAVHV; -.
DR   UniPathway; UPA00704; UER00716.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019404; P:galactitol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01296; Tagatose_aldol_GatZ; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012062; GatZ/KbaZ-like.
DR   InterPro; IPR023436; TagBP_ald_GatZ.
DR   Pfam; PF08013; GatZ_KbaZ-like; 1.
DR   PIRSF; PIRSF009264; TagBP_ald_AgaZ; 1.
DR   TIGRFAMs; TIGR02810; agaZ_gatZ; 1.
PE   3: Inferred from homology;
KW   Galactitol metabolism.
FT   CHAIN           1..420
FT                   /note="D-tagatose-1,6-bisphosphate aldolase subunit GatZ"
FT                   /id="PRO_0000372497"
SQ   SEQUENCE   420 AA;  47022 MW;  9E765977C05F4B6E CRC64;
     MKTLIARHKA GEHIGICSVC SAHPLVIEAA LAFDRNSTRK VLIEATSNQV NQFGGYTGMT
     PADFREFVFA IADKVGFARE RIILGGDHLG PNCWQQENVD AAMEKSVELV KAYVRAGFSK
     IHLDASMSCA GDPIPLAPET VAERAAVLCF AAESVATDCQ REQLSYVIGT EVPVPGGEAS
     AIQSVHITHV EDAANTLRTH QKAFIARGLT EALTRVIAIV VQPGVEFDHS NIIHYQPQEA
     QALAQWIENT RMVYEAHSTD YQTRTAYWEL VRDHFAILKV GPALTFALRE AIFALAQIEQ
     ELIAPENRSG CLAVIEEVML DEPQYWKKYY RTGFNDSLLD IRYSLSDRIR YYWPHSRIKN
     SVETMMVNLQ GVDIPLGMIS QYLPKQFERI QSGELSAIPH QLIMDKIYDV LRAYRYGCAE