ID   GATZ_ECOL6              Reviewed;         420 AA.
AC   Q8FFY8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit GatZ {ECO:0000255|HAMAP-Rule:MF_01296};
GN   Name=gatZ {ECO:0000255|HAMAP-Rule:MF_01296}; OrderedLocusNames=c2620;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase GatYZ
CC       that is required for full activity and stability of the Y subunit.
CC       Could have a chaperone-like function for the proper and stable folding
CC       of GatY. When expressed alone, GatZ does not show any aldolase
CC       activity. Is involved in the catabolism of galactitol.
CC       {ECO:0000255|HAMAP-Rule:MF_01296}.
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_01296}.
CC   -!- SUBUNIT: Forms a complex with GatY. {ECO:0000255|HAMAP-Rule:MF_01296}.
CC   -!- SIMILARITY: Belongs to the GatZ/KbaZ family. GatZ subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01296}.
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DR   EMBL; AE014075; AAN81076.1; -; Genomic_DNA.
DR   RefSeq; WP_000853837.1; NC_004431.1.
DR   STRING; 199310.c2620; -.
DR   EnsemblBacteria; AAN81076; AAN81076; c2620.
DR   KEGG; ecc:c2620; -.
DR   eggNOG; COG4573; Bacteria.
DR   HOGENOM; CLU_053334_0_0_6; -.
DR   OMA; AINAVHV; -.
DR   BioCyc; ECOL199310:C2620-MON; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019404; P:galactitol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01296; Tagatose_aldol_GatZ; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012062; GatZ/KbaZ-like.
DR   InterPro; IPR023436; TagBP_ald_GatZ.
DR   Pfam; PF08013; GatZ_KbaZ-like; 1.
DR   PIRSF; PIRSF009264; TagBP_ald_AgaZ; 1.
DR   TIGRFAMs; TIGR02810; agaZ_gatZ; 1.
PE   3: Inferred from homology;
KW   Galactitol metabolism.
FT   CHAIN           1..420
FT                   /note="D-tagatose-1,6-bisphosphate aldolase subunit GatZ"
FT                   /id="PRO_0000372501"
SQ   SEQUENCE   420 AA;  46990 MW;  EBE27BB446229CD8 CRC64;
     MKTLIARHKA GEHIGICSVC SAHPLVIEAA LAFDRNSTRK VLIEATSNQV NQFGGYTGMT
     PADFREFVFA IADKVGFARE RIILGGDHLG PNCWQQENAD AAMEKSVELV KAYVRAGFSK
     IHLDASMSCA DDSIPLAPET VAERAAVLCL AAESVATDCQ REQLNYVIGT EVPVPGGEAS
     AIQSVHITQV EDAANTLRTH QKAFIARGLA EALTRVIAIV VQPGVEFDHS NIIHYQAQXA
     QALAQWIEKT KMVYEAHSTD YQTQXAYREL VRDHFAILKV GPALTFALRE AIFALAQIEQ
     ELIAPENRSR CLAVIEEVML DEPQYWKKYY RTGFNDSLLD IRYSLSDRIR YYWPHSRIKN
     SVETMMVNLE GVDIPLGMIS QYLPKQFERI QSGELSAIPH QLIMDKIYDV LRAYRYGCAE