GATZ_ECOLI
ID GATZ_ECOLI Reviewed; 420 AA.
AC P0C8J8; P37191; P76414;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit GatZ;
GN Name=gatZ; OrderedLocusNames=b2095, JW2082;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP PROTEIN SEQUENCE OF 1-8.
RC STRAIN=K12;
RX PubMed=17895580; DOI=10.1266/ggs.82.291;
RA Otsuka Y., Koga M., Iwamoto A., Yonesaki T.;
RT "A role of RnlA in the RNase LS activity from Escherichia coli.";
RL Genes Genet. Syst. 82:291-299(2007).
RN [5]
RP ROLE IN GALACTITOL CATABOLISM, AND INDUCTION.
RC STRAIN=K12;
RX PubMed=8955298; DOI=10.1128/jb.178.23.6790-6795.1996;
RA Nobelmann B., Lengeler J.W.;
RT "Molecular analysis of the gat genes from Escherichia coli and of their
RT roles in galactitol transport and metabolism.";
RL J. Bacteriol. 178:6790-6795(1996).
RN [6]
RP FUNCTION AS A TAGBP ALDOLASE COMPONENT, AND COMPLEX WITH GATY.
RC STRAIN=K12;
RX PubMed=11976750; DOI=10.1007/s00203-002-0406-6;
RA Brinkkoetter A., Shakeri-Garakani A., Lengeler J.W.;
RT "Two class II D-tagatose-bisphosphate aldolases from enteric bacteria.";
RL Arch. Microbiol. 177:410-419(2002).
CC -!- FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase GatYZ
CC that is required for full activity and stability of the Y subunit.
CC Could have a chaperone-like function for the proper and stable folding
CC of GatY. When expressed alone, GatZ does not show any aldolase
CC activity. Is involved in the catabolism of galactitol.
CC {ECO:0000269|PubMed:11976750, ECO:0000269|PubMed:8955298}.
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2.
CC -!- SUBUNIT: Forms a complex with GatY.
CC -!- INDUCTION: Constitutively expressed. {ECO:0000269|PubMed:8955298}.
CC -!- SIMILARITY: Belongs to the GatZ/KbaZ family. GatZ subfamily.
CC {ECO:0000305}.
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DR EMBL; U00096; AAC75156.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15965.1; -; Genomic_DNA.
DR PIR; F64976; F64976.
DR PIR; S55902; S55902.
DR RefSeq; NP_416598.1; NC_000913.3.
DR RefSeq; WP_000853883.1; NZ_LN832404.1.
DR AlphaFoldDB; P0C8J8; -.
DR SMR; P0C8J8; -.
DR BioGRID; 4260431; 10.
DR BioGRID; 850986; 1.
DR ComplexPortal; CPX-6023; GatYZ tagatose-1,6-bisphosphate aldolase complex.
DR DIP; DIP-48243N; -.
DR IntAct; P0C8J8; 17.
DR STRING; 511145.b2095; -.
DR jPOST; P0C8J8; -.
DR PaxDb; P0C8J8; -.
DR PRIDE; P0C8J8; -.
DR EnsemblBacteria; AAC75156; AAC75156; b2095.
DR EnsemblBacteria; BAA15965; BAA15965; BAA15965.
DR GeneID; 946641; -.
DR KEGG; ecj:JW2082; -.
DR KEGG; eco:b2095; -.
DR PATRIC; fig|511145.12.peg.2172; -.
DR EchoBASE; EB2317; -.
DR eggNOG; COG4573; Bacteria.
DR HOGENOM; CLU_053334_0_0_6; -.
DR InParanoid; P0C8J8; -.
DR OMA; AINAVHV; -.
DR PhylomeDB; P0C8J8; -.
DR BioCyc; EcoCyc:G7128-MON; -.
DR BioCyc; MetaCyc:G7128-MON; -.
DR SABIO-RK; P0C8J8; -.
DR UniPathway; UPA00704; UER00716.
DR PRO; PR:P0C8J8; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:1902494; C:catalytic complex; IC:ComplexPortal.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008047; F:enzyme activator activity; IMP:EcoCyc.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IC:ComplexPortal.
DR GO; GO:0019404; P:galactitol catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IBA:GO_Central.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_01296; Tagatose_aldol_GatZ; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR012062; GatZ/KbaZ-like.
DR InterPro; IPR023436; TagBP_ald_GatZ.
DR Pfam; PF08013; GatZ_KbaZ-like; 1.
DR PIRSF; PIRSF009264; TagBP_ald_AgaZ; 1.
DR TIGRFAMs; TIGR02810; agaZ_gatZ; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Galactitol metabolism; Reference proteome.
FT CHAIN 1..420
FT /note="D-tagatose-1,6-bisphosphate aldolase subunit GatZ"
FT /id="PRO_0000087433"
SQ SEQUENCE 420 AA; 47109 MW; 258D25D832E42580 CRC64;
MKTLIARHKA GEHIGICSVC SAHPLVIEAA LAFDRNSTRK VLIEATSNQV NQFGGYTGMT
PADFREFVFT IADKVGFARE RIILGGDHLG PNCWQQENAD AAMEKSVELV KEYVRAGFSK
IHLDASMSCA GDPIPLAPET VAERAAVLCF AAESVATDCQ REQLSYVIGT EVPVPGGEAS
AIQSVHITHV EDAANTLRTH QKAFIARGLT EALTRVIAIV VQPGVEFDHS NIIHYQPQEA
QPLAQWIENT RMVYEAHSTD YQTRTAYWEL VRDHFAILKV GPALTFALRE AIFALAQIEQ
ELIAPENRSG CLAVIEEVML DEPQYWKKYY RTGFNDSLLD IRYSLSDRIR YYWPHSRIKN
SVETMMVNLE GVDIPLGMIS QYLPKQFERI QSGELSAIPH QLIMDKIYDV LRAYRYGCAE
