ID   GATZ_ECOLX              Reviewed;         420 AA.
AC   P0C8J9; P37191; P76414;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit GatZ;
GN   Name=gatZ;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EC3132;
RX   PubMed=7772602; DOI=10.1016/0167-4781(95)00053-j;
RA   Nobelmann B., Lengeler J.W.;
RT   "Sequence of the gat operon for galactitol utilization from a wild-type
RT   strain EC3132 of Escherichia coli.";
RL   Biochim. Biophys. Acta 1262:69-72(1995).
RN   [2]
RP   FUNCTION IN GALACTITOL CATABOLISM, AND INDUCTION.
RC   STRAIN=EC3132;
RX   PubMed=8955298; DOI=10.1128/jb.178.23.6790-6795.1996;
RA   Nobelmann B., Lengeler J.W.;
RT   "Molecular analysis of the gat genes from Escherichia coli and of their
RT   roles in galactitol transport and metabolism.";
RL   J. Bacteriol. 178:6790-6795(1996).
CC   -!- FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase GatYZ
CC       that is required for full activity and stability of the Y subunit.
CC       Could have a chaperone-like function for the proper and stable folding
CC       of GatY. When expressed alone, GatZ does not show any aldolase
CC       activity. Is involved in the catabolism of galactitol.
CC       {ECO:0000269|PubMed:8955298}.
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SUBUNIT: Forms a complex with GatY. {ECO:0000250}.
CC   -!- INDUCTION: Constitutively expressed. {ECO:0000269|PubMed:8955298}.
CC   -!- SIMILARITY: Belongs to the GatZ/KbaZ family. GatZ subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA56227.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X79837; CAA56227.1; ALT_FRAME; Genomic_DNA.
DR   RefSeq; WP_001530548.1; NZ_WSWV01000090.1.
DR   AlphaFoldDB; P0C8J9; -.
DR   SMR; P0C8J9; -.
DR   STRING; 585034.ECIAI1_2169; -.
DR   eggNOG; COG4573; Bacteria.
DR   UniPathway; UPA00704; UER00716.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019404; P:galactitol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01296; Tagatose_aldol_GatZ; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012062; GatZ/KbaZ-like.
DR   InterPro; IPR023436; TagBP_ald_GatZ.
DR   Pfam; PF08013; GatZ_KbaZ-like; 1.
DR   PIRSF; PIRSF009264; TagBP_ald_AgaZ; 1.
DR   TIGRFAMs; TIGR02810; agaZ_gatZ; 1.
PE   1: Evidence at protein level;
KW   Galactitol metabolism.
FT   CHAIN           1..420
FT                   /note="D-tagatose-1,6-bisphosphate aldolase subunit GatZ"
FT                   /id="PRO_0000355358"
SQ   SEQUENCE   420 AA;  47120 MW;  055F31769605EDB1 CRC64;
     MKTLIARHKA GEHIGICSVC SAHPLVIEAA LAFDRNSTRK VLIEATSNQV NQFGGYTGMT
     PADFREFVFT IADKVGFARE RIILGGDHLG PNCWQQENAD AAMEKSVELV KAYVRAGFSK
     IHLDASMSCA GDPIPLAPET VAERAAVLCF AAESVATDCQ REQLSYVIGT EVPVPGGEAS
     AIQSVHITRV EDAANTLRTH QKAFIARGLA EALTRVIAIV VQPGVEFDHS NIIHYQPQEA
     QPLAQWIENT RMVYEAHSTD YQTRTAYWEL VRDHFAILKV GPALTFALRE AIFALAQIEQ
     ELIAPENRSG CLAVIEEVMF DEPQYWKKYY RTGFNDSLLD IRYSLSDRIR YYWPHSRIKN
     SVETMMVNLE GMEIPLGMIS QYLPKQFERI QSGELSAIPH QLIMDKIYDV LRAYRYGCAE