ALL7_DERFA
ID ALL7_DERFA Reviewed; 213 AA.
AC Q26456;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Mite allergen Der f 7;
DE AltName: Full=Allergen Der f VII;
DE AltName: Allergen=Der f 7;
DE Flags: Precursor;
GN Name=DERF7;
OS Dermatophagoides farinae (American house dust mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC Pyroglyphidae; Dermatophagoidinae; Dermatophagoides.
OX NCBI_TaxID=6954;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8556554; DOI=10.1111/j.1365-2222.1995.tb00403.x;
RA Shen H.-D., Chua K.-Y., Lin W.L., Hsieh K.-H., Thomas W.R.;
RT "Molecular cloning and immunological characterization of the house dust
RT mite allergen Der f 7.";
RL Clin. Exp. Allergy 25:1000-1006(1995).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC -!- SIMILARITY: Belongs to the mite group 7 allergen family. {ECO:0000305}.
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DR EMBL; S80655; AAB35977.1; -; mRNA.
DR PDB; 3UV1; X-ray; 2.00 A; A/B=18-213.
DR PDBsum; 3UV1; -.
DR AlphaFoldDB; Q26456; -.
DR SMR; Q26456; -.
DR Allergome; 307; Der f 7.
DR Allergome; 3256; Der f 7.0101.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.15.10.50; -; 1.
DR InterPro; IPR038602; Mite_allergen_7_sf.
DR InterPro; IPR020234; Mite_allergen_group-7.
DR Pfam; PF16984; Grp7_allergen; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Allergen; Glycoprotein; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..213
FT /note="Mite allergen Der f 7"
FT /id="PRO_0000001184"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT HELIX 24..41
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 43..51
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 54..61
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 63..79
FT /evidence="ECO:0007829|PDB:3UV1"
FT HELIX 81..83
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 84..89
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 91..95
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 98..110
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 112..122
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 128..136
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 139..150
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 153..159
FT /evidence="ECO:0007829|PDB:3UV1"
FT STRAND 163..169
FT /evidence="ECO:0007829|PDB:3UV1"
FT HELIX 177..211
FT /evidence="ECO:0007829|PDB:3UV1"
SQ SEQUENCE 213 AA; 23627 MW; 3CF1F529107B7808 CRC64;
MMKFLLIAAV AFVAVSADPI HYDKITEEIN KAIDDAIAAI EQSETIDPMK VPDHADKFER
HVGIVDFKGE LAMRNIEARG LKQMKRQGDA NVKGEEGIVK AHLLIGVHDD IVSMEYDLAY
KLGDLHPTTH VISDIQDFVV ALSLEISDEG NITMTSFEVR QFANVVNHIG GLSILDPIFG
VLSDVLTAIF QDTVRKEMTK VLAPAFKREL EKN