ID   GATZ_ECOSM              Reviewed;         420 AA.
AC   B1LN93;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit GatZ {ECO:0000255|HAMAP-Rule:MF_01296};
GN   Name=gatZ {ECO:0000255|HAMAP-Rule:MF_01296};
GN   OrderedLocusNames=EcSMS35_0969;
OS   Escherichia coli (strain SMS-3-5 / SECEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=439855;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMS-3-5 / SECEC;
RX   PubMed=18708504; DOI=10.1128/jb.00661-08;
RA   Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA   Ravel J., Stepanauskas R.;
RT   "Insights into the environmental resistance gene pool from the genome
RT   sequence of the multidrug-resistant environmental isolate Escherichia coli
RT   SMS-3-5.";
RL   J. Bacteriol. 190:6779-6794(2008).
CC   -!- FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase GatYZ
CC       that is required for full activity and stability of the Y subunit.
CC       Could have a chaperone-like function for the proper and stable folding
CC       of GatY. When expressed alone, GatZ does not show any aldolase
CC       activity. Is involved in the catabolism of galactitol.
CC       {ECO:0000255|HAMAP-Rule:MF_01296}.
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_01296}.
CC   -!- SUBUNIT: Forms a complex with GatY. {ECO:0000255|HAMAP-Rule:MF_01296}.
CC   -!- SIMILARITY: Belongs to the GatZ/KbaZ family. GatZ subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01296}.
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DR   EMBL; CP000970; ACB17032.1; -; Genomic_DNA.
DR   RefSeq; WP_000853855.1; NC_010498.1.
DR   AlphaFoldDB; B1LN93; -.
DR   SMR; B1LN93; -.
DR   EnsemblBacteria; ACB17032; ACB17032; EcSMS35_0969.
DR   KEGG; ecm:EcSMS35_0969; -.
DR   HOGENOM; CLU_053334_0_0_6; -.
DR   OMA; AINAVHV; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000007011; Chromosome.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019404; P:galactitol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01296; Tagatose_aldol_GatZ; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012062; GatZ/KbaZ-like.
DR   InterPro; IPR023436; TagBP_ald_GatZ.
DR   Pfam; PF08013; GatZ_KbaZ-like; 1.
DR   PIRSF; PIRSF009264; TagBP_ald_AgaZ; 1.
DR   TIGRFAMs; TIGR02810; agaZ_gatZ; 1.
PE   3: Inferred from homology;
KW   Galactitol metabolism.
FT   CHAIN           1..420
FT                   /note="D-tagatose-1,6-bisphosphate aldolase subunit GatZ"
FT                   /id="PRO_0000372493"
SQ   SEQUENCE   420 AA;  46802 MW;  6F0D0FD0FFA1DC12 CRC64;
     MKTLIARHKA GEHIGICSVC SAHPLVIEAA LAFDRNSTRK VLIEATSNQV NQFGGYTGMT
     PADFREFVFA IANKVGFARE RIILGGDHLG PNCWQQENAD AAMEKSVELV KAYVRAGFSK
     IHLDASMSCA GDPIPLAPET VAERAAVLCL AAESVATDCQ REQLSYVIGT EVPVPGGEAS
     AIQSVHITQV EDAANTLRTH QKAFIARGLA EALTRVIAIV VQPGVEFDHS NIIHYQAQEA
     QALAQWIEKT KMVYEAHSTD YQTQAAYREL VRDHFAILKV GPALTFALRE AVFALAQIEQ
     ELIAPENRSG CLAVIEEVML DEPQYWKKYY RTGFHDSLLD IRYSLSDRIR YYWPHSRIKN
     SVETMMVNLE GVDIPLGMIS QYLPKQFERI QSGELSAIPH QLIMDKIYDV LRAYRYGCAE